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The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Arun C. Habermann, Austin J. Gutierrez, Linh T. Bui, et al.

AND

Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis

Taylor S. Adams, Jonas C. Schupp, Sergio Poli, et al.

Negative frequency-dependent selection maintains coexisting genotypes during fluctuating selection

Caroline B. Turner, Sean W. Buskirk, Katrina B. Harris, et al.

The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactions

Maire Gavagan, Elizabeth Speltz, Jesse Zalatan

Discussion

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

Kanagaraj Subramanian, Darren M Hutt, Vijay Gupta, et al.

Aging is associated with a systemic length-driven transcriptome imbalance

Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, et al.

Discussion

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

Richard J. Wheeler, Hyun O. Lee, Ina Poser, et al.

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

Michael S. Woody, Donald A. Winkelmann, Marco Capitanio, et al.

Discussion

The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cells

Alan S. Wang, Leo Chen, R. Alex Wu, et al.

Discussion

Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet Therapy

Jantzen Sperry, Janel E. Le Belle, Michael C. Condro, et al.

Discussion

Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

Julia TCW, Shuang A. Liang, Lu Qian, et al.

Octopi: Open configurable high-throughput imaging platform for infectious disease diagnosis in the field

Hongquan Li, Hazel Soto-Montoya, Maxime Voisin, et al.

Discussion