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A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, et al.

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Eva Mejía-Ramírez, Pablo Iañez Picazo, Barbara Walter, et al.

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

Raphaël Pantier, Elisa Barbieri, Sara Gonzalez Brito, et al.

Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation

Marika Oksanen, Francesca Mastropasqua, Krystyna Mazan-Mamczarz, et al.

Discussion

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

Jens Bager Christensen, Alex P.A. Donovan, Marzieh Moradi, et al.

IMMClock reveals immune aging and T cell function at single-cell resolution

Yael Gurevich Schmidt, Di Wu, Sanna Madan, et al.

Adenine DNA methylation associated to transcription is widespread across eukaryotes

Pedro Romero Charria, Cristina Navarrete, Vladimir Ovchinnikov, et al.

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepulveda, Xiang Li, Xiaojing Yue, et al.

Discussion

Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments

Martina Begnis, Julien Duc, Sandra Offner, et al.

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

Luke A. Sarre, Iana V. Kim, Vladimir Ovchinnikov, et al.

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotency

Fides Zenk, Jonas Simon Fleck, Sophie Martina Johanna Jansen, et al.