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CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.



Selected by Jessica Chevallier, Pierre Caron

PYCR1 Levels Track with Premature and Chronological Skin Aging

Kortessa Sotiropoulou, Saniye Yumlu, Tomoko Hirano, et al.



Selected by Preethi Krishnaraj

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

Nanami Senoo, Dinesh K. Chinthapalli, Matthew G. Baile, et al.



Selected by Barbora Knotkova

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, et al.



Selected by Amanda Ivanoff

DNA methylation rates scale with maximum lifespan across mammals

Samuel. J. C. Crofts, Eric Latorre-Crespo, Tamir Chandra



Selected by Jennifer Ann Black

Biologically informed NeuralODEs for genome-wide regulatory dynamics

Intekhab Hossain, Viola Fanfani, John Quackenbush, et al.



Selected by Benjamin Dominik Maier

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, et al.



Selected by UofA IMB565

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.



Selected by Jennifer Ann Black

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

Sangeetha Srinivasan, Nathan A. Yee, Michael Zakharian, et al.



Selected by Zhang-He Goh

Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

Agata Gluszek-Kustusz, Benjamin Craske, Thibault Legal, et al.



Selected by Divya Pathak, Barbora Knotkova

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, et al.

AND

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

Jiayue Chen, Renbo Yu, Na Li, et al.



Selected by Marc Somssich, Gwendolyn K. Kirschner

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, et al.



Selected by Preethi Krishnaraj
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