CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity
Selected by
Jessica Chevallier, Pierre Caron
PYCR1 Levels Track with Premature and Chronological Skin Aging
Selected by
Preethi Krishnaraj
Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
Selected by
Barbora Knotkova
A transposase-derived gene required for human brain development
Selected by
Amanda Ivanoff
DNA methylation rates scale with maximum lifespan across mammals
Selected by
Jennifer Ann Black
Biologically informed NeuralODEs for genome-wide regulatory dynamics
Selected by
Benjamin Dominik Maier
Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
Selected by
UofA IMB565
EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells
Selected by
Jennifer Ann Black
SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species
Selected by
Zhang-He Goh
Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis
Selected by
Divya Pathak, Barbora Knotkova
Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane
AND
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants
Selected by
Marc Somssich, Gwendolyn K. Kirschner
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
Selected by
Preethi Krishnaraj