My name is Mariana De Niz. I am a postdoctoral fellow at the Institute of Molecular Medicine in Lisbon, Portugal. My work focuses on understanding the biophysics and dynamics of the parasite Trypanosoma brucei (causative of sleeping sickness), in various tissues of mammalian hosts. I am particularly interested in microscopy methods to image host-parasite interactions, and am keen on developing new methods that enable visualising and investigating these interactions. In my PhD and first postdoc, I worked on investigating various stages of the malaria-causative parasite Plasmodium. I was particularly interested in understanding parasite tropism and mechanisms of sequestration during Plasmodium blood stages, and host cell organelle manipulation during Plasmodium liver stage development.
Adaptive cell invasion maintains organ homeostasis
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Force requirements of endocytic vesicle formation
Mariana De Niz
![Biophysics Biophysics](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/biophysics.png)
Real-Time Multi-Angle Projection Imaging of Biological Dynamics
Mariana De Niz
![Bioengineering Bioengineering](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/bioengineering.png)
Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Microtissue geometry and cell-generated forces drive patterning of liver progenitor cell differentiation in 3D
Mariana De Niz
![Biophysics Biophysics](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/biophysics.png)
Modelling disease transmission from touchscreen user interfaces
Mariana De Niz
![Epidemiology Epidemiology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/epidemiology.png)
AMP-activated protein kinase: A key enzyme to manage nutritional stress responses in parasites with complex life cycles
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Automated Detection and Diameter Estimation for Mouse Mesenteric Artery using Semantic Segmentation
Mariana De Niz
![Developmental Biology Developmental Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/developmental-biology.png)
Single cell sequencing of the small and AT-skewed genome of malaria parasites
Mariana De Niz
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
Fluorescent tagging of Plasmodium circumsporozoite protein allows imaging of sporozoite formation but blocks egress from oocysts
Mariana De Niz
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)