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A Scube2-Shh feedback loop links morphogen release to morphogen signaling to enable scale invariant patterning of the ventral neural tube

Zach Collins, Kana Ishimatsu, Tony Tsai, et al.

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains

Christ Leemans, Marloes van der Zwalm, Laura Brueckner, et al.

Refolding activity of bacterial Hsp90 in vivo reveals ancient chaperoning function

Tania Moran Luengo, Toveann Ahlnas, Anna T. Hoekstra, et al.

Discussion

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

Charles A Seller, Chun-Yi Cho, Patrick H O'Farrell

Discussion

The landscape of antigen-specific T cells in human cancers

Bo Li, Longchao Liu, Jian Zhang, et al.

Tension on kinetochore substrates is insufficient to prevent Aurora-triggered detachment

Anna K de Regt, Charles L Asbury, Sue Biggins

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient

Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, et al.

Molecular organization of integrin-based adhesion complexes in mouse Embryonic Stem Cells

Shumin Xia, Evelyn K.F. Yim, Pakorn Kanchanawong

AND

Superresolution architecture of pluripotency guarding adhesions

Aki Stubb, Camilo Guzmán, Elisa Närvä, et al.

Discussion

Revealing the nanoscale morphology of the primary cilium using super-resolution fluorescence microscopy

Joshua Yoon, Colin J. Comerci, Lucien E. Weiss, et al.

Discussion

Three-dimensional tissue stiffness mapping in the mouse embryo supports durotaxis during early limb bud morphogenesis

Min Zhu, Hirotaka Tao, Mohammad Samani, et al.

Discussion

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Florian Kopp, Mehmet Yalvac, Beibei Chen, et al.

Discussion

Target-specific precision of CRISPR-mediated genome editing

Anob M Chakrabarti, Tristan Henser-Brownhill, Josep Monserrat, et al.