Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models
Selected by
11 January 2025
Jawdat Sandakly

Germplasm stability in zebrafish requires maternal Tdrd6a and Tdrd6c
Selected by
13 December 2024
Justin Gutkowski

Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery
Selected by
07 November 2024
Manuel Lessi

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia
Selected by
22 August 2024
Gustavo Stelzer, Marcus Oliveira

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice
Selected by
22 August 2024
Gustavo Stelzer, Marcus Oliveira

Mechano-dependent sorbitol accumulation supports biomolecular condensate
Selected by
07 September 2023
Teodora Piskova

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease
Selected by
19 August 2021
Kristina Kuhbandner

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly
Selected by
05 June 2021
Joanna Zell

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating other proteins aggregation
Selected by
20 May 2021
Eric McGregor

A “spindle and thread”-mechanism unblocks translation of N-terminally disordered proteins
Selected by
16 April 2021
Utrecht Protein Folding and Assembly

Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones
Selected by
14 April 2021
Utrecht Protein Folding and Assembly

Brain deletion of Serf2 shifts amyloid conformation in a mouse model
Selected by
06 April 2021
Utrecht Protein Folding and Assembly
