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Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models

Nalini R. Rao, Olivia DeGulis, Toshihiro Nomura, et al.

Selected by 11 January 2025

Jawdat Sandakly

Neuroscience

Germplasm stability in zebrafish requires maternal Tdrd6a and Tdrd6c

Alessandro Consorte, Yasmin El Sherif, Fridolin Kielisch, et al.

Selected by 13 December 2024

Justin Gutkowski

Developmental Biology

Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

Yanru Ji, Xiaoling Chen, Meek Connor Joseph, et al.

Selected by 07 November 2024

Manuel Lessi

Neuroscience

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

Roxan A. Stephenson, Kory R. Johnson, Linling Cheng, et al.

Selected by 22 August 2024

Gustavo Stelzer, Marcus Oliveira

Biochemistry

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

Christa C. Huber, Eduardo Callegari, Maria Paez, et al.

Selected by 22 August 2024

Gustavo Stelzer, Marcus Oliveira

Biochemistry

Mechano-dependent sorbitol accumulation supports biomolecular condensate

Stephanie Torrino, William M Oldham, Andrés R Tejedor, et al.

Selected by 07 September 2023

Teodora Piskova

Cell Biology

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

Constanze Depp, Ting Sun, Andrew Octavian Sasmita, et al.

Selected by 19 August 2021

Kristina Kuhbandner

Neuroscience

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, et al.

Selected by 05 June 2021

Joanna Zell

Biochemistry

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating other proteins aggregation

Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, et al.

Selected by 20 May 2021

Eric McGregor

Cell Biology

A “spindle and thread”-mechanism unblocks translation of N-terminally disordered proteins

Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, et al.

Selected by 16 April 2021

Utrecht Protein Folding and Assembly

Biochemistry

Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

Unekwu M. Yakubu, Kevin A. Morano

Selected by 14 April 2021

Utrecht Protein Folding and Assembly

Biochemistry

Brain deletion of Serf2 shifts amyloid conformation in a mouse model

E. Stroo, L. Janssen, O. Sin, et al.

Selected by 06 April 2021

Utrecht Protein Folding and Assembly

Molecular Biology