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The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Jeanette A.I. Johnson, Genevieve L. Stein-O’Brien, Max Booth, et al.

Discussion

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, et al.

Optical Control of G-Actin with a Photoswitchable Latrunculin

Nynke A. Vepřek, Madeline H. Cooper, Laura Laprell, et al.

Mechano-dependent sorbitol accumulation supports biomolecular condensate

Stephanie Torrino, William M Oldham, Andrés R Tejedor, et al.

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Discussion

A Phosphoproteomics Data Resource for Systems-level Modeling of Kinase Signaling Networks

Song Feng, James A. Sanford, Thomas Weber, et al.

Similarity metric learning on perturbational datasets improves functional identification of perturbations

Ian Smith, Petr Smirnov, Benjamin Haibe-Kains

The landscape of biomedical research

Rita González-Márquez, Luca Schmidt, Benjamin M. Schmidt, et al.

AND

ChatGPT identifies gender disparities in scientific peer review

Jeroen P.H. Verharen

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

Fatima Rizvi, Yu-Ri Lee, Ricardo Diaz-Aragon, et al.

Small extracellular vesicles promote stiffness-mediated metastasis

Alexandra Sneider, Ying Liu, Bartholomew Starich, et al.

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

Joshua Okletey, Dimitrios Angelis, Tia M. Jones, et al.