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A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, et al.

Selected by 15 June 2021

María Mariner-Faulí

Developmental Biology

Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death

Gal Ofir, Ehud Herbst, Maya Baroz, et al.

Selected by 05 February 2021

Jonny Coates, Connor Rosen

Cell Biology

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

Baker N., Catta-Preta C.M.C., Neish R., et al.

Selected by 18 December 2020

Mariana De Niz

Cell Biology

Primary sex determination in chickens depends on DMRT1 dosage, but gonadal sex does not determine secondary sexual characteristics in adult birds

Jason Ioannidis, Gunes Taylor, Debiao Zhao, et al.

Selected by 14 October 2020

Martin Estermann

Developmental Biology

Generating single-sex litters: development of crispr-cas9 genetic tools to produce all-male offspring

Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, et al.

Selected by 07 October 2020

Martin Estermann

Developmental Biology

In response to Li et al.: Linker histones function in Drosophila embryogenesis

Albert Carbonell, Lazslo Henn, Juan Pérez-Roldán, et al.

Selected by 29 September 2020

Sree Rama Chaitanya

Molecular Biology

Frizzled-dependent Planar Cell Polarity without Wnt Ligands

Joyce J.S. Yu, Aude Maugarny-Calès, Stéphane Pelletier, et al.

AND

Wnt ligands are not required for planar cell polarity in the Drosophila wing or notum

Ben Ewen-Campen, Typhaine Comyn, Eric Vogt, et al.

Selected by 10 August 2020

Helen Zenner

Guide RNA categorization enables target site choice in Tn7-crispr-cas transposons

Michael T. Petassi, Shan-Chi Hsieh, Joseph E. Peters

Selected by 16 July 2020

haridha shivram

Bioinformatics

Organoid Easytag: an efficient workflow for gene targeting in human organoids

Dawei Sun, Lewis D. Evans, Emma L. Rawlins

Selected by 22 May 2020

Kirsty Ferguson

Developmental Biology

Parallel crispr-cas9 screens clarify impacts of p53 on screen performance

Anne Ramsay Bowden, David A. Morales Juarez, Matylda Sczaniecka-Clift, et al.

Selected by 27 April 2020

Mila Basic

Cell Biology

The Taste of Blood in Mosquitoes

Veronica Jové, Zhongyan Gong, Felix J.H. Hol, et al.

Selected by 23 April 2020

Vaibhav Menon

Animal Behavior and Cognition

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, et al.

Selected by 20 March 2020

Georgina Sava

Cancer Biology