Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair
Selected by
15 December 2023
Pierre Caron
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity
Selected by
06 September 2023
Jessica Chevallier, Pierre Caron
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis
Selected by
05 June 2023
Pierre Caron
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells
Selected by
15 May 2023
Jennifer Ann Black
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
Selected by
03 May 2023
Preethi Krishnaraj
![Neuroscience Neuroscience](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/neuroscience.png)
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis
Selected by
09 March 2023
Pierre Caron
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)
Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation
Selected by
20 June 2022
Pierre Caron
![Biochemistry Biochemistry](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/biochemistry.png)
ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations
Selected by
17 February 2022
Jennifer Ann Black
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases
Selected by
15 December 2021
Louise Moyle et al.
![Genomics Genomics](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/genomics.png)
Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites
Selected by
10 August 2021
Giuseppina D'Alessandro
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair
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06 January 2021
Giuseppina D'Alessandro, Sree Rama Chaitanya
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
EccDNA formation is dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA double-strand break
Selected by
05 January 2021
Sree Rama Chaitanya
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)