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Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma

Alina Ritter, Malenka Zimmermann, Florian H. Geyer, et al.

Discussion

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRAS^G12C suppresses PI3Kα and leads to potent tumor inhibition

Katherine Parker, Samar Ghorbanpoor, Wafa Malik, et al.

Discussion

Prenatal Stress Differentially Shapes Adult Behavior in Male and Female Offspring

Erbo Dong, Alison Chu, Tamar Gur, et al.

Discussion

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

Phong T. Nguyen, Zheng Wu, Dohun Kim, et al.

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

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Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

Self-renewal of neuronal mitochondria through asymmetric division

Tejashree Pradip Waingankar, Camryn Zurita, Angelica E. Lang, et al.

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

Abrar Bhat, Amit Das, Meenakshi Iyer, et al.

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

William S. Stuart, Michail N. Isupov, Mathew McLaren, et al.

Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling

Joyce C. M. Meiring, Varsha Mahapatra, Molly S.C. Gravett, et al.

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

Julien Pigeon, Tamina Dietl, Myriame Abou Mrad, et al.

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

Daniel A. Reed, Anna E. Howell, Nadia Kuepper, et al.

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

Diana Angelica Aguilar-Ayala, Marie Sylvianne Rabodoarivelo, Maxime R. Eveque-Mourroux, et al.

Discussion