My name is Monica Tambalo and I am a postdoctoral researcher in Dr. Simona Lodato’s lab at the IRCCS Humanitas Clinical and Research Center in Milan. My research focuses on understanding the molecular mechanisms of neurogenesis and linking them to neurodevelopmental diseases. In my preLights, I will be mainly talking about cell fate decisions, brain development, and the emerging potential of organoids as human model systems.
I graduated in Molecular Biology from the University of Padua in 2010, after spending one year as an Erasmus student in Paris where I studied at the Master of genetics (Paris Diderot University) and worked in the laboratory of Dr. Jamilé Hazan. I then joined Prof. Andrea Streit lab for my PhD in the Centre of Craniofacial & Regenerative Biology at King’s College London. There my work aimed at deciphering the molecular mechanisms regulating the early cell fate decisions of sensory progenitors, with a focus on how inner ear precursors are established. In 2015, I joined Dr. David Wilkinson’s lab at the Francis Crick Institute where I studied how neurogenesis becomes patterned within the developing zebrafish hindbrain. I am now working in Dr. Simona Lodato’s lab, supported by the Umberto Veronesi Foundation Fellowship. I am currently investigating cell fate decisions in the human cortex and the impact of infantile epilepsy in cortical development.
Generating human neural diversity with a multiplexed morphogen screen in organoids
Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart
Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development
Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues
An early cell shape transition drives evolutionary expansion of the human forebrain
An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum
Early neurulation recapitulated in assemblies of embryonic and extraembryonic cells