Chee Kiang (Ethan) Ewe received his BS(Hons) in Biomedical Science from the University of Auckland, New Zealand, in 2015. He earned his PhD at the University of California, Santa Barbara where he studied the regulatory logic governing developmental robustness and the molecular basis underlying variation in the endoderm gene regulatory network in C. elegans under the guidance of Dr. Joel Rothman. He is currently a Postdoctoral Researcher in Dr. Oded Rechavi’s lab at Tel Aviv University, studying the molecular basis of epigenetic inheritance.
Preprint highlights, selected by the biological community
Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition
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15 February 2024
Chee Kiang Ewe
Patterned embryonic invagination evolved in response to mechanical instability
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Divergent evolutionary strategies preempt tissue collision in fly gastrulation
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13 December 2023
Reinier Prosee et al.
LincRNAs enable germ cells differentiation by promoting PUF proteins condensation
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30 October 2023
Umutcan Kaan Bozan et al.
Ancient origins of complex neuronal genes
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23 October 2023
Preethi Krishnaraj, Chee Kiang Ewe
Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart
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12 July 2023
Chee Kiang Ewe, Preethi Krishnaraj
Insights from a survey of mentorship experiences by graduate and postdoctoral researchers
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17 May 2023
Chee Kiang Ewe et al.
daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans
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11 May 2023
Chee Kiang Ewe
Restructuring of an asymmetric neural circuit during associative learning
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30 January 2023
Chee Kiang Ewe
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation
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05 December 2022
Chee Kiang Ewe
An intestinal sphingolipid promotes neuronal health across generations
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29 August 2022
Chee Kiang Ewe
The ELT-3 GATA factor specifies endoderm in Caenorhabditis angaria in an ancestral gene network
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11 June 2022
Chee Kiang Ewe
Maintenance of neurotransmitter identity by Hox proteins through a homeostatic mechanism
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16 May 2022
Chee Kiang Ewe
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation
This work was recently published in Nature Aging. It has been great to follow the journey of this paper from preprint to published article. Notably, the key conclusions presented in the revised paper largely mirror those from the preprint. The preprint demonstrated that TGFβ signaling is required for the cell non-autonomous UPRER activation in response…
| Posted on | 1 September 2023 |
An intestinal sphingolipid promotes neuronal health across generations
This work was recently published in Nature Cell Biology. It has been great to follow the journey of this paper from preprint to published article. The major conclusions in the revised paper largely remain unchanged, with two important improvements: (1) In the revised paper, the authors provided the mechanism by which UA and S1P improve…
| Posted on | 8 August 2023 |
The ELT-3 GATA factor specifies endoderm in Caenorhabditis angaria in an ancestral gene network
This preprint was recently published in Development. In the peer-reviewed article, the authors included an updated high quality whole genome sequence of C. angaria, which will aid future comparative studies with C. elegans. The authors also expanded their smFISH analysis to C. monodelphis and showed that elt-3 is expressed in the embryonic endoderm, as observed…
| Posted on | 26 October 2022 |
Maintenance of neurotransmitter identity by Hox proteins through a homeostatic mechanism
This work has identified the gene regulatory network underlying the maintenance of neurotransmitter identity in C. elegans. The preprint was very well written and the major conclusions were well supported by the genetic data. In the published version of the article, the authors further probed the functional significance of the gene network and showed that…
| Posted on | 31 October 2022 |
