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Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

Charles L. Evavold, Iva Hafner-Bratkovič, Jonathan C. Kagan

Discussion

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Ruilin Tian, Anthony Abarientos, Jason Hong, et al.

DMD-based super-resolution structured illumination microscopy visualizes live cell dynamics at high speed and low cost

Alice Sandmeyer, Mario Lachetta, Hauke Sandmeyer, et al.

Discussion

Mitophagy protects beta cells from inflammatory damage in diabetes

Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, et al.

Stem-cell niche self-restricts the signaling range via receptor-ligand degradation

Sophia Ladyzhets, Matthew Antel, Taylor Simao, et al.

Discussion

Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

Megan K Oliva, Juan José Perez-Moreno, Jillian O’Shaughnessy, et al.

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism

Wei Wei, Gary Ruvkun

Discussion

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation

Sun Y. Maybury-Lewis, Abigail K. Brown, Mitchell Yeary, et al.

Discussion

ER-Mitochondria Contacts Promote Mitochondrial-Derived Compartment Biogenesis

Alyssa M. English, Benoît Kornmann, Janet M. Shaw, et al.

AND

Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress

Max-Hinderk Schuler, Alyssa M. English, Thane J. Campbell, et al.

Discussion

Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressors

Jeremy J. Work, Onn Brandmann

Discussion

The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces

Yingxue Wang, Weijiao Zhang, Matthew Jefferson, et al.

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

Xiaoshan Shi, Adam L. Yokom, Chunxin Wang, et al.

Discussion