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The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, et al.

Selected by Sergio Menchero

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque

Paul Cheng, Robert C. Wirka, Juyong Brian Kim, et al.

Selected by Debbie Ho

Association analysis of repetitive elements and R-loop formation across species

Chao Zeng, Masahiro Onoguchi, Michiaki Hamada

Selected by Sree Rama Chaitanya

Evolution of mouse circadian enhancers from transposable elements

Julius Judd, Hayley Sanderson, Cédric Feschotte

Selected by Miguel V. Almeida

The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection

Jialin Liu, Rebecca R. Viales, Pierre Khoueiry, et al.

Selected by Irepan Salvador-Martinez

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, et al.

Selected by Sree Rama Chaitanya

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

Eunhee Yi, Amit D. Gujar, Molly Guthrie, et al.

Selected by Sree Rama Chaitanya

Genome-wide maps of enhancer regulation connect risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, et al.

Selected by Jesus Victorino

Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males

Kevin H.-C. Wei, Lauren Gibilisco, Doris Bachtrog

Selected by Hann Ng

Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes

Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, et al.

Selected by Jesus Victorino

Upregulation and cell specificity of C₄ genes are derived from ancestral C₃ gene regulatory networks

Pallavi Singh, Sean R. Stevenson, Ivan Reyna-Llorens, et al.

Selected by Ying Sun

CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains

Hui Huang, Quan Zhu, Adam Jussila, et al.

Selected by Clarice Hong