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Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.

Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP

James Chapman, Hanna Salmonowicz, Stella Victorelli, et al.

Discussion

RNA targeting with CRISPR-Cas13a facilitates bacteriophage genome engineering

Jingwen Guan, Agnès Oromí-Bosch, Senén D. Mendoza, et al.

Yersinia pestis genomes reveal plague in Britain 4,000 years ago

Pooja Swali, Rick Schulting, Alexandre Gilardet, et al.

Discussion

Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts

Odemaris Narvaez del Pilar, Jichao Chen

Borgs are giant extrachromosomal elements with the potential to augment methane oxidation

Basem Al-Shayeb, Marie C. Schoelmerich, Jacob West-Roberts, et al.

SARS-CoV-2 Variants are Selecting for Spike Protein Mutations that Increase Protein Stability

David Shorthouse, Benjamin. A. Hall

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates

Andrea Toth, Shelby Steinmeyer, Paranthaman Kannan, et al.

Discussion

Development of the foregut in Katharina tunicata (Mollusca; Polyplacophora)

Brandy S. Biggar

Discussion

Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

Alvaro Baeza Garcia, Edwin Siu, Xin Du, et al.

Skeletal muscle mitochondrial dysfunction in mice is linked to bone loss via the bone marrow immune microenvironment

Jingwen Tian, Ji Sun Moon, Ha Thi Nga, et al.

Discussion

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum

Felix Evers, Alfredo Cabrera-Orefice, Dei M. Elurbe, et al.