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Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection in Pre-Clinical Models

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, et al.

Selected by 27 November 2020

Alexander Ward, Osvaldo Contreras

Bioengineering

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

Moheb Ghobrial, Jason Charish, Shigeki Takada, et al.

Selected by 21 October 2020

Kristina Kuhbandner

Neuroscience

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection

Shubhanshi Trivedi, Allie H. Grossmann, Owen Jensen, et al.

Selected by 30 September 2020

Josie Gibson

Immunology

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice

Yuki Nishimoto, Kazuhiro Ito, Genki Kimura, et al.

Selected by 23 September 2020

Zhang-He Goh

Pharmacology and Toxicology

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

Laura Pellegrini, Anna Albecka, Donna L. Mallery, et al.

Selected by 18 September 2020

Theresa Pohlkamp

Cell Biology

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Jean Farup, Jesper Just, Frank de Paoli, et al.

Selected by 10 September 2020

Osvaldo Contreras, Nicolas Collao

Bioinformatics

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, KE Lewis, AK Walker, et al.

Selected by 01 August 2020

Kristina Kuhbandner

Neuroscience

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

AND

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Selected by 31 July 2020

Yen-Chung Chen

Immunology

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

AND

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Selected by 25 July 2020

Zhang-He Goh, Josie Gibson

Pharmacology and Toxicology

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

Silvia Ferrara, Alice Rossi, Serena Ranucci, et al.

Selected by 25 July 2020

Zhang-He Goh

Pharmacology and Toxicology

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

Jaymin J. Kathiriya, Chaoqun Wang, Alexis Brumwell, et al.

Selected by 24 July 2020

Julio Sainz de Aja

Cell Biology

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth during early tuberculosis

Vivek V. Thacker, Neeraj Dhar, Kunal Sharma, et al.

Selected by 15 July 2020

Snehal Kadam

Microbiology