Search results

Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection in Pre-Clinical Models

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, et al.

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

Moheb Ghobrial, Jason Charish, Shigeki Takada, et al.

Discussion

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection

Shubhanshi Trivedi, Allie H. Grossmann, Owen Jensen, et al.

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice

Yuki Nishimoto, Kazuhiro Ito, Genki Kimura, et al.

Discussion

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

Laura Pellegrini, Anna Albecka, Donna L. Mallery, et al.

Human skeletal muscle CD90⁺ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Jean Farup, Jesper Just, Frank de Paoli, et al.

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, KE Lewis, AK Walker, et al.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

AND

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

AND

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Discussion

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

Silvia Ferrara, Alice Rossi, Serena Ranucci, et al.

Discussion

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

Jaymin J. Kathiriya, Chaoqun Wang, Alexis Brumwell, et al.

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth during early tuberculosis

Vivek V. Thacker, Neeraj Dhar, Kunal Sharma, et al.