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Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

Anne Ramsay Bowden, David A. Morales Juarez, Matylda Sczaniecka-Clift, et al.

Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance

Michael M. Maiden, Christopher M. Waters

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

Jonathan D. Winkelman, Caitlin A. Anderson, Cristian Suarez, et al.

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Mechanosensing through direct binding of tensed F-actin by LIM domains

Xiaoyu Sun, Donovan Y. Z. Phua, Lucas Axiotakis Jr., et al.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, et al.

Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive inter- and intra-enhancer redundancy

A. Hörnblad, K. Langenfeld, S. Bastide, et al.

Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses

Chris J. de Witte, Jose Espejo Valle-Inclan, Nizar Hami, et al.

bioRxiv: the preprint server for biology

Richard Sever, Ted Roeder, Samantha Hindle, et al.

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

Irina A. Okkelman, Nuno Neto, Dmitri B. Papkovsky, et al.

A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, et al.

GenEPi: Piezo1-based fluorescent reporter for visualizing mechanical stimuli with high spatiotemporal resolution

Sine Yaganoglu, Nordine Helassa, Benjamin M. Gaub, et al.

Identification of a master regulator of differentiation in Toxoplasma

Benjamin S. Waldman, Dominic Schwarz, Marc H. Wadsworth II, et al.

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening

Olya Mastikhina, Byeong-Ui Moon, Kenneth Williams, et al.