Toxicology of toxicants, existing therapeutics, and investigational drugs
Preprints that describe the toxicology of environmental pollutants and existing and upcoming drugs. Includes both toxicokinetics and toxicodynamics, as well as technological improvements that will help in the characterisation of this field.
List by Zhang-He Goh
Preprints:
Are Zinc oxide nanoparticles safe? A structural study on human serum albumin using in vitro and in silico methods
https://www.biorxiv.org/content/10.1101/503797v2
Zinc Oxide (ZnO) nanoparticles are heavily used in various biomedical and formulation applications. In their preprint, Hassanian et al. investigate the toxicity of ZnO nanoparticles, using in vitro and in silico studies to understand the effects that ZnO nanoparticles have on human serum albumin (HSA).
A Bile Duct-on-a-Chip with Organ-Level Functions
https://www.biorxiv.org/content/10.1101/594291v1
The bile duct-on-a-chip invention by Du et al. could be used to further explore the hepatobiliary tree, investigate pharmacokinetic testing phases of drug discovery, and understand the hepatobiliary system more holistically. Taken together, these would aid in efforts to characterise how drugs and toxins might affect the entire hepatobiliary system.
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FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
| List by | Ana Dorrego-Rivas |
COVID-19 / SARS-CoV-2 preprints
List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic
| List by | Dey Lab, Zhang-He Goh |
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Drug use in special populations
Any drugs that are being used in special populations: Patients with liver and kidney failure, in paediatrics, in geriatrics, and in pregnant or lactating patients. Includes the discovery of factors that could potentially affect drug use in these special populations.
| List by | Zhang-He Goh |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Anticancer agents: Discovery and clinical use
Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.
| List by | Zhang-He Goh |
Advances in Drug Delivery
Advances in formulation technology or targeted delivery methods that describe or develop the distribution of small molecules or large macromolecules to specific parts of the body.
| List by | Zhang-He Goh |
Also in the pharmacology and toxicology category:
Pervasive sublethal effects of agrochemicals as contributing factors to insect decline
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets