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Toxicology of toxicants, existing therapeutics, and investigational drugs

Preprints that describe the toxicology of environmental pollutants and existing and upcoming drugs. Includes both toxicokinetics and toxicodynamics, as well as technological improvements that will help in the characterisation of this field.

List by Zhang-He Goh

Preprints:

Are Zinc oxide nanoparticles safe? A structural study on human serum albumin using in vitro and in silico methods

Marziyeh Hassanian, Hassan Aryapour, Alireza Goudarzi, Masoud Bezi Javan

https://www.biorxiv.org/content/10.1101/503797v2

Zinc Oxide (ZnO) nanoparticles are heavily used in various biomedical and formulation applications. In their preprint, Hassanian et al. investigate the toxicity of ZnO nanoparticles, using in vitro and in silico studies to understand the effects that ZnO nanoparticles have on human serum albumin (HSA).

A Bile Duct-on-a-Chip with Organ-Level Functions

Yu Du, Gauri Khandekar, Jessica Llewellyn, William Polacheck, Christopher S. Chen, Rebecca G. Wells

https://www.biorxiv.org/content/10.1101/594291v1

The bile duct-on-a-chip invention by Du et al. could be used to further explore the hepatobiliary tree, investigate pharmacokinetic testing phases of drug discovery, and understand the hepatobiliary system more holistically. Taken together, these would aid in efforts to characterise how drugs and toxins might affect the entire hepatobiliary system.

Categories: pharmacology and toxicology

 

Posted on: 5th June 2019

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