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Zhang-He Goh

Agency for Science, Technology and Research (A*STAR) Singapore, University of Cambridge

I am a Pharmacy graduate from the National University of Singapore (NUS) with a research interest in organic synthesis, toxicology, and infectious diseases. In October 2020, I will be joining the University of Cambridge’s Syntech CDT to embark on my doctoral studies in Chemistry.

I have been affiliated with the Agency for Science, Technology, and Research (A*STAR) since 2011, and have worked in the following Research Institutes (RIs):

In NUS, my undergraduate research work consisted of two research projects that revolved around tuberculosis: 1) discovering antitubercular agents that utilise new mechanisms of action against Mycobacterium tuberculosis, and 2) finding ways to reduce side effects of the tuberculosis drug regimens in use.

Zhang-He Goh has added 37 highlights

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice

Yuki Nishimoto, Kazuhiro Ito, Genki Kimura, et al.



Selected by Zhang-He Goh

Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

Patricia Rueda, Jon Merlin, Stefano Chimenti, et al.



Selected by Zhang-He Goh

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype

Hafeez S. Haniff, Xiaohui Liu, Laurent Knerr, et al.



Selected by Zhang-He Goh

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Ghazal Babolmorad, Asna Latif, Niall M. Pollock, et al.

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Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Francisco Inesta-Vaquera, Panida Navasumrit, Colin J. Henderson, et al.



Selected by Zhang-He Goh

Electron Transfer from Cytochrome P450 Reductase to Cytochrome P450: Towards a Structural and Dynamic Understanding

Goutam Mukherjee, Prajwal P. Nandekar, Rebecca C. Wade



Selected by Zhang-He Goh

Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control Mycobacterium tuberculosis infection in macrophages

Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, et al.



Selected by Josie Gibson, Zhang-He Goh

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Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

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Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.



Selected by Zhang-He Goh, Josie Gibson

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

Silvia Ferrara, Alice Rossi, Serena Ranucci, et al.



Selected by Zhang-He Goh

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein



Selected by Zhang-He Goh

Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model

Kristina M. Bigelow, Rokeya Tasneen, Yong S. Chang, et al.



Selected by Zhang-He Goh

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, et al.



Selected by Zhang-He Goh

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A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, et al.



Selected by Zhang-He Goh

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