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Zhang-He Goh

University of Cambridge, Agency for Science, Technology and Research (A*STAR) Singapore

I am a Pharmacy graduate from the National University of Singapore (NUS) with a research interest in organic synthesis, toxicology, and infectious diseases. In October 2020, I embarked on my doctoral studies in Chemistry as part of the University of Cambridge’s Syntech CDT.

I have been affiliated with the Agency for Science, Technology, and Research (A*STAR) since 2011, and have worked in the following Research Institutes (RIs):

In NUS, my undergraduate research work consisted of two research projects that revolved around tuberculosis: 1) discovering antitubercular agents that utilise new mechanisms of action against Mycobacterium tuberculosis, and 2) finding ways to reduce side effects of the tuberculosis drug regimens in use.

 

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Zhang-He Goh has added 49 preLight posts

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

John M. Bennett, Sunil K. Narwal, Stephanie Kabeche, et al.



Selected by Zhang-He Goh

Optical Control of G-Actin with a Photoswitchable Latrunculin

Nynke A. Vepřek, Madeline H. Cooper, Laura Laprell, et al.



Selected by Zhang-He Goh

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

Sangeetha Srinivasan, Nathan A. Yee, Michael Zakharian, et al.



Selected by Zhang-He Goh

DNA-enhanced CuAAC ligand enables live-cell detection of intracellular biomolecules

Keqing Nian, Yifang Liu, Laura Brigandi, et al.



Selected by Zhang-He Goh

Multifunctional fluorophores for live-cell imaging and affinity capture of proteins

Pratik Kumar, Jason D. Vevea, Edwin R. Chapman, et al.



Selected by Zhang-He Goh

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

Madeline E. Kavanagh, Benjamin D. Horning, Roli Khattri, et al.



Selected by Zhang-He Goh

High-throughput aminoacyl-tRNA synthetase engineering for genetic code expansion in yeast

Jessica T. Stieglitz, James A. Van Deventer



Selected by Zhang-He Goh

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry

Michael Riffle, Michael R. Hoopmann, Daniel Jaschob, et al.



Selected by Zhang-He Goh

The Design, Synthesis, and Evaluation of Hypoxia-Activated Prodrugs of the KDAC Inhibitor Panobinostat

Ewen Calder, Anna Skwarska, Deborah Sneddon, et al.



Selected by Zhang-He Goh

Design of smart antibody mimetics with photosensitive switches

Lian He, Peng Tan, Yun Huang, et al.



Selected by Zhang-He Goh

Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors

Andrew J. Jezewski, Yu-Hsi Lin, Julie A. Reisz, et al.



Selected by Zhang-He Goh

Systematic Engineering of Artificial Metalloenzymes for New-to-Nature Reactions

Tobias Vornholt, Fadri Christoffel, Michela M. Pellizzoni, et al.



Selected by Zhang-He Goh

Zhang-He Goh has collaborated with:

Zhang-He Goh's recent preLists

COVID-19 / SARS-CoV-2 preprints

List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic

 



List by Dey Lab, Zhang-He Goh

1

Drug use in special populations

Any drugs that are being used in special populations: Patients with liver and kidney failure, in paediatrics, in geriatrics, and in pregnant or lactating patients. Includes the discovery of factors that could potentially affect drug use in these special populations.

 



List by Zhang-He Goh

Toxicology of toxicants, existing therapeutics, and investigational drugs

Preprints that describe the toxicology of environmental pollutants and existing and upcoming drugs. Includes both toxicokinetics and toxicodynamics, as well as technological improvements that will help in the characterisation of this field.

 



List by Zhang-He Goh

Antimicrobials: Discovery, clinical use, and development of resistance

Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.

 



List by Zhang-He Goh

Anticancer agents: Discovery and clinical use

Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.

 



List by Zhang-He Goh

Advances in Drug Delivery

Advances in formulation technology or targeted delivery methods that describe or develop the distribution of small molecules or large macromolecules to specific parts of the body.

 



List by Zhang-He Goh

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