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Zhang-He Goh

Agency for Science, Technology and Research (A*STAR) Singapore

I am a Pharmacy graduate from the National University of Singapore with a research interest in organic synthesis, toxicology, and infectious diseases. I am working in the Experimental Drug Development Centre (EDDC), a Research Institute that is part of the Agency for Science, Technology, and Research (A*STAR) research entities.

My undergraduate research work consisted of two research projects that revolved around tuberculosis: 1) discovering antitubercular agents that utilise new mechanisms of action against Mycobacterium tuberculosis, and 2) finding ways to reduce side effects of the tuberculosis drug regimens in use.

Zhang-He Goh has added 28 highlights

Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model

Kristina M. Bigelow, Rokeya Tasneen, Yong S. Chang, et al.



Selected by Zhang-He Goh

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, et al.



Selected by Zhang-He Goh

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A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, et al.



Selected by Zhang-He Goh

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, et al.



Selected by Zhang-He Goh

The antimicrobial peptide DGL13K is active against resistant gram-negative bacteria and subinhibitory concentrations stimulate bacterial growth without causing resistance

Sven-Ulrik Gorr, Hunter V. Brigman, Jadyn C. Anderson, et al.



Selected by Zhang-He Goh

A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Robert J. Nims, Lara Pferdehirt, Noelani B. Ho, et al.



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Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

J. Stone Doggett, Tracey Schultz, Alyssa J. Miller, et al.



Selected by Zhang-He Goh

Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses

Chris J. de Witte, Jose Espejo Valle-Inclan, Nizar Hami, et al.



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Effective buprenorphine use and tapering strategies: Endorsements and insights by people in recovery from opioid use disorder on a Reddit forum

Rachel L Graves, Abeed Sarker, Mohammed Ali Al-Garadi, et al.



Selected by Zhang-He Goh

Combining antibiotics with antivirulence compounds is effective and can reverse selection for antibiotic resistance in Pseudomonas aeruginosa

Chiara Rezzoagli, Martina Archetti, Michael Baumgartner, et al.



Selected by Zhang-He Goh

COMET: A toolkit for composing customizable genetic programs in mammalian cells

Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, et al.



Selected by Zhang-He Goh

Engineering Phage Host-Range and Suppressing Bacterial Resistance Through Phage Tail Fiber Mutagenesis

Kevin Yehl, Sébastien Lemire, Andrew C. Yang, et al.



Selected by Zhang-He Goh

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