STING mediates immune responses in a unicellular choanoflagellate

Arielle Woznica, Ashwani Kumar, Carolyn R. Sturge, et al.

AND

The STING ligand 2’3’-cGAMP induces an NF-κB-dependent anti-bacterial innate immune response in the starlet sea anemone Nematostella vectensis

Shally R. Margolis, Peter A. Dietzen, Beth M. Hayes, et al.

Discussion

On-person adaptive evolution of Staphylococcus aureus during atopic dermatitis increases disease severity

Felix M. Key, Veda D. Khadka, Carolina Romo-González, et al.

Discussion

Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death

Gal Ofir, Ehud Herbst, Maya Baroz, et al.

Discussion

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

Charles L. Evavold, Iva Hafner-Bratkovič, Jonathan C. Kagan

Discussion

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

Sabrina I. Green, Carmen Gu Liu, Xue Yu, et al.

Discussion

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation

Hamish W King, Nara Orban, John C Riches, et al.

Discussion

Immune factor of bacterial origin protects ticks against host microbial commensals

Beth M. Hayes, Atanas D. Radkov, Fauna Yarza, et al.

Discussion

Conflicts with diarrheal pathogens trigger rapid evolution of an intestinal signaling axis

Clayton M. Carey, Sarah E. Apple, Zoё A. Hilbert, et al.

Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects

Snehal N. Chaudhari, David A. Harris, Hassan Aliakbarian, et al.

Discussion

Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

Calum C. Bain, Douglas A. Gibson, Nicholas Steers, et al.

Discussion

Colibactin DNA damage signature indicates causative role in colorectal cancer

Paulina J. Dziubańska-Kusibab, Hilmar Berger, Federica Battistini, et al.

Discussion

Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans

Ryan A. Flynn, Benjamin A. H. Smith, Alex G. Johnson, et al.

Discussion