I am a scientist at the Agency for Science, Technology, and Research (A*STAR), and currently work at the Institute Of Sustainability for Chemicals, Energy And Environment (ISCE2).
I completed my PhD in Chemistry at the University of Cambridge in 2025. Before that, I was a Pharmacy graduate from the National University of Singapore (NUS) (2019).
My first foray into research was in 2011 as a young scientist at the Institute of Materials Research and Engineering (IMRE). Since then, I have worked in the following Research Entities (REs):
- Experimental Drug Development Centre (EDDC) (2019 – 2020)
- Bioinformatics Institute (BII) (2017)
- Institute of Bioengineering and Nanotechnology (2015)
My graduate research revolved around developing hypervalent iodine reagents for protein functionalisation. Before that, my undergraduate research work consisted of two research projects that revolved around tuberculosis: 1) discovering antitubercular agents that utilise new mechanisms of action against Mycobacterium tuberculosis, and 2) finding ways to reduce side effects of the tuberculosis drug regimens in use.
Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors
Zhang-He Goh
Systematic Engineering of Artificial Metalloenzymes for New-to-Nature Reactions
Zhang-He Goh
Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice
Zhang-He Goh
Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Zhang-He Goh
Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype
Zhang-He Goh
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
AND
Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
Zhang-He Goh
Electron Transfer from Cytochrome P450 Reductase to Cytochrome P450: Towards a Structural and Dynamic Understanding
Zhang-He Goh
Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control Mycobacterium tuberculosis infection in macrophages
Josie Gibson, Zhang-He Goh
Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen
AND
Tamoxifen reduces inflammatory infiltration of neutrophils in the airways
Zhang-He Goh, Josie Gibson
The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection
Zhang-He Goh
Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports
AND
Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia
Zhang-He Goh
Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model
Zhang-He Goh
2 years
Zhang-He Goh
Thank you for pointing this out! I have now edited the Figure accordingly.