I am a Pharmacy graduate from the National University of Singapore (NUS) with a research interest in organic synthesis, toxicology, and infectious diseases. In October 2020, I embarked on my doctoral studies in Chemistry as part of the University of Cambridge’s Syntech CDT.
I have been affiliated with the Agency for Science, Technology, and Research (A*STAR) since 2011, and have worked in the following Research Institutes (RIs):
- Experimental Drug Development Centre (EDDC) (2019 – 2020)
- Bioinformatics Institute (BII) (2017)
- Institute of Bioengineering and Nanotechnology (now IBB) (2015)
- Institute of Materials Research and Engineering (IMRE) (2011 – 2012)
In NUS, my undergraduate research work consisted of two research projects that revolved around tuberculosis: 1) discovering antitubercular agents that utilise new mechanisms of action against Mycobacterium tuberculosis, and 2) finding ways to reduce side effects of the tuberculosis drug regimens in use.
Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice
Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
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Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
Electron Transfer from Cytochrome P450 Reductase to Cytochrome P450: Towards a Structural and Dynamic Understanding
Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control Mycobacterium tuberculosis infection in macrophages
Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen
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Tamoxifen reduces inflammatory infiltration of neutrophils in the airways
The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection
Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports
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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia
Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model
Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism
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Zhang-He Goh
Thank you for pointing this out! I have now edited the Figure accordingly.