Synthetic mammalian signaling circuits for robust cell population control

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Retrospective identification of rare cell populations underlying drug resistance connects molecular variability with cell fate

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Automated continuous evolution of proteins in vivo

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Axon-like protrusions promote small cell lung cancer migration and metastasis

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Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells

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Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

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Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice Gurbatri, Courtney Coker, Taylor E. Hinchliffe, et al.

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Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury, Taylor E Hinchliffe, Samuel Castro, et al.

Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacteria via Dynamic RNA Nanotechnology

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Disrupting Transcriptional Feedback Yields an Escape-Resistant Antiviral

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