Drug use in special populations
Any drugs that are being used in special populations: Patients with liver and kidney failure, in paediatrics, in geriatrics, and in pregnant or lactating patients. Includes the discovery of factors that could potentially affect drug use in these special populations.
List by Zhang-He Goh
Preprints:
Dosing regimen of gentamicin and the effect of antenatal steroids on clearance in preterm infants
https://www.biorxiv.org/content/10.1101/566125v1
Gentamicin is a well-known antibiotic that exhibits an uncommon profile in paediatrics, which makes the optimisation of its dosing and administration especially difficult. By targeting this problem in their preprint, Santos et al. help to improve clinical knowledge of gentamicin’s unique dosing regimen in paediatric patients.
Functional potential of bacterial strains in the premature infant gut microbiome is associated with gestational age
https://www.biorxiv.org/content/10.1101/530139v1
Rahman et al. characterise the constitution and diversity of infant gut microbiomes in their preprint, providing insight into “diseases associated with dysbiosis of the microbiome” and, indirectly, shedding light on potential differences in the ways that therapeutics may be administered to paediatric patients.
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Register hereAlso in the pharmacology and toxicology category:
April in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics
| List by | Vibha SINGH et al. |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
| List by | Ana Dorrego-Rivas |
COVID-19 / SARS-CoV-2 preprints
List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic
| List by | Dey Lab, Zhang-He Goh |
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Toxicology of toxicants, existing therapeutics, and investigational drugs
Preprints that describe the toxicology of environmental pollutants and existing and upcoming drugs. Includes both toxicokinetics and toxicodynamics, as well as technological improvements that will help in the characterisation of this field.
| List by | Zhang-He Goh |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Anticancer agents: Discovery and clinical use
Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.
| List by | Zhang-He Goh |
Advances in Drug Delivery
Advances in formulation technology or targeted delivery methods that describe or develop the distribution of small molecules or large macromolecules to specific parts of the body.
| List by | Zhang-He Goh |
Also in the pharmacology and toxicology category:
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis
Zhang-He Goh
Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity
Daniel Fernando Reyes Enríquez, Marcus Oliveira
Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal
Yan Aveiro dos Reis, Marcus Oliveira
