Toxicology of toxicants, existing therapeutics, and investigational drugs
Preprints that describe the toxicology of environmental pollutants and existing and upcoming drugs. Includes both toxicokinetics and toxicodynamics, as well as technological improvements that will help in the characterisation of this field.
List by Zhang-He Goh
Preprints:
Are Zinc oxide nanoparticles safe? A structural study on human serum albumin using in vitro and in silico methods
https://www.biorxiv.org/content/10.1101/503797v2
Zinc Oxide (ZnO) nanoparticles are heavily used in various biomedical and formulation applications. In their preprint, Hassanian et al. investigate the toxicity of ZnO nanoparticles, using in vitro and in silico studies to understand the effects that ZnO nanoparticles have on human serum albumin (HSA).
A Bile Duct-on-a-Chip with Organ-Level Functions
https://www.biorxiv.org/content/10.1101/594291v1
The bile duct-on-a-chip invention by Du et al. could be used to further explore the hepatobiliary tree, investigate pharmacokinetic testing phases of drug discovery, and understand the hepatobiliary system more holistically. Taken together, these would aid in efforts to characterise how drugs and toxins might affect the entire hepatobiliary system.
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April in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics
| List by | Vibha SINGH et al. |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
| List by | Ana Dorrego-Rivas |
COVID-19 / SARS-CoV-2 preprints
List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic
| List by | Dey Lab, Zhang-He Goh |
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Drug use in special populations
Any drugs that are being used in special populations: Patients with liver and kidney failure, in paediatrics, in geriatrics, and in pregnant or lactating patients. Includes the discovery of factors that could potentially affect drug use in these special populations.
| List by | Zhang-He Goh |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Anticancer agents: Discovery and clinical use
Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.
| List by | Zhang-He Goh |
Advances in Drug Delivery
Advances in formulation technology or targeted delivery methods that describe or develop the distribution of small molecules or large macromolecules to specific parts of the body.
| List by | Zhang-He Goh |
Also in the pharmacology and toxicology category:
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis
Zhang-He Goh
Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity
Daniel Fernando Reyes Enríquez, Marcus Oliveira
Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal
Yan Aveiro dos Reis, Marcus Oliveira
