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Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses

Chris J. de Witte, Jose Espejo Valle-Inclan, Nizar Hami, et al.

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

Irina A. Okkelman, Nuno Neto, Dmitri B. Papkovsky, et al.

GeneWalk identifies relevant gene functions for a biological context using network representation learning

Robert Ietswaart, Benjamin M. Gyori, John A. Bachman, et al.

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching

Jasper Wouters, Zeynep Kalender-Atak, Liesbeth Minnoye, et al.

Discussion

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening

Olya Mastikhina, Byeong-Ui Moon, Kenneth Williams, et al.

Discussion

The spindle assembly checkpoint functions during early development in non-chordate embryos

Janet Chenevert, Marianne Roca, Lydia Besnardeau, et al.

Discussion

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

Adrian Janiszewski, Irene Talon, Juan Song, et al.

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Sherine E. Thomas, Andrew J. Whitehouse, Karen Brown, et al.

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar, Victoria Korboukh, Peter Doig, et al.

Discussion

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

Rhea Jessica Longley, Michael T White, Eizo Takashima, et al.

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Antimalarial drug mefloquine kills both trophozoite and cyst stages of Entamoeba

Conall Sauvey, Gretchen Ehrenkaufer, Anjan Debnath, et al.

Discussion

A direct selection strategy for isolating aptamers with pH-sensitive binding activity

Chelsea K L Gordon, Michael Eisenstein, H T Soh

Discussion

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

Alexander Swoboda, Robert Soukup, Katharina Kinslechner, et al.

Discussion