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Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, et al.



Selected by Joanna Zell

1

Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

Unekwu M. Yakubu, Kevin A. Morano



Selected by Utrecht Protein Folding and Assembly

1

Brain deletion of Serf2 shifts amyloid conformation in a mouse model

E. Stroo, L. Janssen, O. Sin, et al.



Selected by Utrecht Protein Folding and Assembly

1

Structure of an infectious mammalian prion

Allison Kraus, Forrest Hoyt, Cindi L. Schwartz, et al.



Selected by Jennifer Ann Black

2

Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

Ryan R. Cupo, James Shorter



Selected by Tessa Sinnige

1

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

Jessica Tittelmeier, Carl Alexander Sandhof, Heidrun Maja Ries, et al.



Selected by Tessa Sinnige

1

The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell



Selected by Tessa Sinnige

1

Elucidating the molecular determinants of Aβ aggregation with deep mutational scanning

Vanessa E Gray, Katherine Sitko, Floriane Z. Ngako Kameni, et al.



Selected by Suzanne McDermott

Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity

Edoardo Salladini, Claire Debarnot, Vincent Delauzun, et al.



Selected by Tessa Sinnige

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Diego Gauto, Leandro Estrozi, Charles Schwieters, et al.



Selected by Reid Alderson

1

Structure of a cytochrome-based bacterial nanowire

David J Filman, Stephen F Marino, Joy E Ward, et al.



Selected by Amberley Stephens

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient

Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, et al.



Selected by Tessa Sinnige

1

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