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Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

Patricia Rueda, Jon Merlin, Stefano Chimenti, et al.

Discussion

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

Marine Luciano, Shi-Lei Xue, Winnok H. De Vos, et al.

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Ghazal Babolmorad, Asna Latif, Niall M. Pollock, et al.

AND

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Francisco Inesta-Vaquera, Panida Navasumrit, Colin J. Henderson, et al.

Discussion

Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injury

Catalina Sierra-Ramos, Silvia Velazquez-Garcia, Ayse G. Keskus, et al.

EllipTrack: A Global-Local Cell-Tracking Pipeline for 2D Fluorescence Time-Lapse Microscopy

Chengzhe Tian, Chen Yang, Sabrina L. Spencer

Discussion

Organoid Easytag: an efficient workflow for gene targeting in human organoids

Dawei Sun, Lewis D. Evans, Emma L. Rawlins

Differentiation of human intestinal organoids with endogenous vascular endothelial cells

Emily M. Holloway, Joshua H. Wu, Michael Czerwinkski, et al.

Discussion

In situ structure determination of virus capsids imaged within cell nuclei by correlative light and cryo-electron tomography

Swetha Vijayakrishnan, Marion McElwee, Colin Loney, et al.

TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

Ruochen Zang, Maria F.G. Castro, Broc T. McCune, et al.

Discussion

The molecular structure of primary cilia revealed by cryo-electron tomography

Petra Kiesel, Gonzalo Alvarez Viar, Nikolai Tsoy, et al.

Hnf4a-mediated regulation of proximal tubule progenitors in the mouse kidney

Sierra S. Marable, Eunah Chung, Joo-Seop Park

Discussion

NINJA: an inducible genetic model for creating neoantigens in vivo

Martina Damo, Brittany Fitzgerald, Yisi Lu, et al.