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Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, et al.

Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses

Chris J. de Witte, Jose Espejo Valle-Inclan, Nizar Hami, et al.

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

Poonam Thakur, Kelvin Luk, Jochen Roeper

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation

Simone Cristina da Silva Rosa, Matthew D. Martens, Jared T. Field, et al.

Combining antibiotics with antivirulence compounds is effective and can reverse selection for antibiotic resistance in Pseudomonas aeruginosa

Chiara Rezzoagli, Martina Archetti, Michael Baumgartner, et al.

Ferroptosis contributes to developmental cell death in rice blast

Qing Shen, Meiling Liang, Fan Yang, et al.

Epigenetic gene silencing by heterochromatin primes fungal resistance

Sito Torres-Garcia, Pauline N. C. B. Audergon, Manu Shukla, et al.

From ridge tops to ravines: landscape drivers of chimpanzee ranging patterns

Samantha J. Green, Bryan J. Boruff, Cyril C. Grueter

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Chimpanzees use advanced spatial cognition to plan least-cost routes

Samantha J. Green, Bryan J. Boruff, Cyril C. Grueter

Hif-1alpha stabilisation is protective against infection in a zebrafish model of comorbidity

Yves Schild, Abdirizak Mohamed, Edward J. Wootton, et al.

Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells

Paul Briaud, Laura Camus, Sylvère Bastien, et al.

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

Kanagaraj Subramanian, Darren M Hutt, Vijay Gupta, et al.

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching

Jasper Wouters, Zeynep Kalender-Atak, Liesbeth Minnoye, et al.