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Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

AND

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion

Subthreshold voltage Analysis Demonstrates Neuronal Cell-Surface Sialic Acids Modulate Excitability and Network Integration

Rishikesh U. Kulkarni, Catherine L. Wang, Carolyn R. Bertozzi

Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex

Nora Jamann, Dominik Dannehl, Robin Wagener, et al.

Opposing influence of top-down and bottom-up input on different types of excitatory layer 2/3 neurons in mouse visual cortex

Rebecca Jordan, Georg Keller

Depression of heart rate in fish at critically high temperatures is due to atrioventricular block

Jaakko Haverinen, Matti Vornanen

On-demand spatiotemporal programming of collective cell migration via bioelectric stimulation

Tom J. Zajdel, Gawoon Shim, Linus Wang, et al.

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

Poonam Thakur, Kelvin Luk, Jochen Roeper

Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment

Amr Abouelezz, Holly Stefen, Mikael Segerstråle, et al.

ORP5 Transfers Phosphatidylserine To Mitochondria And Regulates Mitochondrial Calcium Uptake At Endoplasmic Reticulum - Mitochondria Contact Sites

Leila Rochin, Cecile Sauvanet, Eeva Jaaskelainen, et al.

Discussion

Optical determination of absolute membrane potential

Julia R. Lazzari-Dean, Anneliese M.M. Gest, Evan Miller

Discussion

A DNA-based voltmeter for organelles

Anand Saminathan, John Devany, Kavya S Pillai, et al.

Regulation of modulatory cell activity across olfactory structures in Drosophila melanogaster

Xiaonan Zhang, Kaylynn Coates, Andrew Dacks, et al.