Biomolecular NMR
Preprints related to the application and development of biomolecular NMR spectroscopy
List by Reid Alderson
Preprints:
Dynamic Aha1 Co-Chaperone Binding to Human Hsp90
https://www.biorxiv.org/content/10.1101/550228v1
Atomic-level details about the interaction between Hsp90 and its co-chaperone Aha1
Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
https://www.biorxiv.org/content/10.1101/498287v1
Combines limited data from cryo-EM and solution- and solid-state NMR to determine structural models of a 500 kDa protein
Dynamics and interactions of ADP/ATP transporter AAC3 in DPC detergent are not functionally relevant
https://www.biorxiv.org/content/10.1101/317669v2
Data from NMR show that the the membrane protein AAC3 reconstituted in detergent is partially unfolded and inactive
Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy
https://www.biorxiv.org/content/10.1101/612135v1
Application of 15N spin relaxation and H/D exchange to investigate the structural and dynamical features of an amyloidogenic protein
Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator
https://www.biorxiv.org/content/10.1101/301853v1
Spin relaxation experiments characterize changes to backbone and methyl side-chain dynamics in the presence and absence of DNA. Allosteric changes upon zinc binding are identified through NMR. Now published in eLife https://elifesciences.org/articles/37268
Structural basis and mechanism of the unfolding-induced activation of an acid response chaperone HdeA
https://www.biorxiv.org/content/10.1101/390104v1
Residual structure and dynamics of the acid-unfolded chaperone HdeA are determined, and chemical exchange saturation transfer (CEST) and 19F NMR provide additional insight into the mechanism of HdeA. Now published in J. Biol. Chem. http://www.jbc.org/content/294/9/3192
Structural basis for terminal loop recognition and processing of pri-miRNA-18a by hnRNP A1
https://www.biorxiv.org/content/10.1101/178855v3
NMR used in combination with other biophysical methods to determine the structure of a protein-RNA complex. Now published in Nat. Commun. https://www.nature.com/articles/s41467-018-04871-9
Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution
https://www.biorxiv.org/content/10.1101/185009v1
Usage of relaxation dispersion to characterize millisecond dynamics in the enzyme CypA and variants thereof obtained through directed evolution. Now published in Nat. Commun. https://www.nature.com/articles/s41467-018-03562-9
Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization
https://www.biorxiv.org/content/10.1101/189050v1
Protein folding on the ribosome studied by NMR. Now published in Proc. Natl. Acad. Sci. USA https://www.pnas.org/content/115/39/9744.long
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