Biophysical Society Meeting 2020

Some preprints presented at the Biophysical Society Meeting 2020 in San Diego, USA.

List by Tessa Sinnige

Preprints:

Phase Transition of RNA-protein Complexes into Ordered Hollow Condensates

Ibraheem Alshareedah, Mahdi Muhammad Moosa, Muralikrishna Raju, Davit Potoyan, Priya R. Banerjee

https://www.biorxiv.org/content/10.1101/2020.01.10.902353v1

Phase separation was a hot topic yet again at this year’s Biophysical Society Meeting. This preprint extends the landscape of liquid-liquid phase separation to some very interesting structures including hollow condensates.

Allosteric action of nucleotides on Hsp90 across several time- and length scales

Steffen Wolf, Benedikt Sohmen, Björn Hellenkamp, Johann Thurn, Gerhard Stock, Thorsten Hugel

https://www.biorxiv.org/content/10.1101/2020.02.15.950725v1

Hsp90 is a dimeric molecular chaperone that is thought to aid protein folding by a series of conformational changes driven by ATP hydrolysis, although the precise mechanism is still unclear. Using single molecule fluorescence measurements and molecular dynamics simulations, this study demonstrates that nucleotide binding and hydrolysis affect the overall Hsp90 dimer by allosteric mechanisms.

Divergent ion selectivity and sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs of DEG/ENaC/ASIC channels in C. elegans

S. Fechner, I. D’Alessandro, L. Wang, C. Tower, L. Tao, M.B. Goodman

https://www.biorxiv.org/content/10.1101/2020.02.12.946681v1?rss=1

The class of ion channels studied in this work are important drug targets for e.g. anti-inflammatory molecules. The authors here express five channels derived from C. elegans in Xenopus laevis oocytes to probe their properties in detail, leading to the surprising finding that they differ in their ion sensitivities and modulation by small molecules.

Kinetic fingerprint of antibody therapies predicts outcomes of Alzheimer clinical trials

Sara Linse, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Christopher M. Dobson, Samuel I. A. Cohen, Eimantas Sileikis, Martin Lundquist, Fang Qian, Tiernan O’Malley, Thierry Bussiere, Paul H. Weinreb, Catherine K. Xu, Georg Meisl, Sean Devenish, Tuomas P. J. Knowles, Oskar Hansson

https://www.biorxiv.org/content/10.1101/815308v1

Clinical trials for Alzheimer’s disease have been notoriously unsuccessful over the past years. This study uses elegant methods to demonstrate why one antibody that recently showed some effect in clinical trials acts on amyloid-beta aggregation via a unique mechanism.

A Tug of War Between Condensate Phases in a Minimal Macromolecular System

Archishman Ghosh, Xiaojia Zhang, Huan-Xiang Zhou

https://www.biorxiv.org/content/10.1101/2020.01.29.925099v1

More phase separation: this study shows the interplay between four components in condensate formation, to better understand the behaviour of complex biomolecular mixtures such as membrane-less organelles.

Categories: biophysics

Posted on: 24 February 2020

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