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Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection in Pre-Clinical models

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, et al.

Genetically-Modified Macrophages Accelerate Myelin Repair

Vanja Tepavčević, Gaelle Dufayet-Chaffaud, Marie-Stephane Aigrot, et al.

Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors

Andrew J. Jezewski, Yu-Hsi Lin, Julie A. Reisz, et al.

Discussion

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice

Yuki Nishimoto, Kazuhiro Ito, Genki Kimura, et al.

Discussion

Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages

Elisenda Alsina-Sanchis, Ronja Mülfarth, Iris Moll, et al.

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Laura Pasetto, Stefano Callegaro, Deborah Ferrara, et al.

Human skeletal muscle CD90⁺ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Jean Farup, Jesper Just, Frank de Paoli, et al.

Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

Patricia Rueda, Jon Merlin, Stefano Chimenti, et al.

Discussion

The effect of absent blood flow on the zebrafish cerebral and trunk vasculature

Elisabeth Kugler, Ryan Snodgrass, George Bowley, et al.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart disease

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, et al.

Discussion

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, KE Lewis, AK Walker, et al.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

AND

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion