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A Scube2-Shh feedback loop links morphogen release to morphogen signaling to enable scale invariant patterning of the ventral neural tube

Zach Collins, Kana Ishimatsu, Tony Tsai, et al.

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

Salah Mahmoudi, Elena Mancini, Alessandra Moore, et al.

Discussion

Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive elimination of unspecified cells

Masakazu Hashimoto, Hiroshi Sasaki

Discussion

Systematic identification of human SNPs affecting regulatory element activity

Joris van Arensbergen, Ludo Pagie, Vincent FitzPatrick, et al.

DNA microscopy: Optics-free spatio-genetic imaging by a stand-alone chemical reaction

Joshua A. Weinstein, Aviv Regev, Feng Zhang

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

Julien Delile, Teresa Rayon, Manuela Melchionda, et al.

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains

Christ Leemans, Marloes van der Zwalm, Laura Brueckner, et al.

The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner

Federico Germani, Daniel Hain, Denise Sternlicht, et al.

Discussion

Refolding activity of bacterial Hsp90 in vivo reveals ancient chaperoning function

Tania Moran Luengo, Toveann Ahlnas, Anna T. Hoekstra, et al.

Discussion

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

Charles A Seller, Chun-Yi Cho, Patrick H O'Farrell

Discussion

Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells

Mridusmita Saikia, Philip Burnham, Sara H Keshavjee, et al.

AND

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

Mandeep Singh, Ghamdan Al-Eryani, Shaun Carswell, et al.

Discussion

The landscape of antigen-specific T cells in human cancers

Bo Li, Longchao Liu, Jian Zhang, et al.