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Microtubules tune mechanosensitive cell responses

Shailaja Seetharaman, Benoit Vianay, Vanessa Roca, et al.

Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

Patricia Rueda, Jon Merlin, Stefano Chimenti, et al.

Discussion

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype

Hafeez S. Haniff, Xiaohui Liu, Laurent Knerr, et al.

Discussion

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

L Caló, E Hidari, M Wegrzynowicz, et al.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, et al.

Discussion

Optoribogenetic control of regulatory RNA molecules

Sebastian Pilsl, Charles Morgan, Moujab Choukeife, et al.

Electron Transfer from Cytochrome P450 Reductase to Cytochrome P450: Towards a Structural and Dynamic Understanding

Goutam Mukherjee, Prajwal P. Nandekar, Rebecca C. Wade

Discussion

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

Nataliia Serbyn, Ivona Bagdiul, Agnès H. Michel, et al.

Expansion Microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid

Eloïse Bertiaux, Aurélia C Balestra, Lorène Bournonville, et al.

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

Jerome AJ Becker, Lucie P Pellissier, Yannick Corde, et al.

Discussion

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

Radoslaw P. Kozak, Karina Mondragon-Shem, Christopher Williams, et al.

Discussion

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

AND

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion