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Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

AND

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Discussion

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

Nataliia Serbyn, Ivona Bagdiul, Agnès H. Michel, et al.

Guide RNA categorization enables target site choice in Tn7-CRISPR-Cas transposons

Michael T. Petassi, Shan-Chi Hsieh, Joseph E. Peters

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

Jerome AJ Becker, Lucie P Pellissier, Yannick Corde, et al.

Discussion

An open-source experimental framework for automation of cell biology experiments

Pavel Katunin, Ashley Cadby, Anton Nikolaev

Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke

Amy N. Adkins, Julius P.A. Dewald, Lindsay Garmirian, et al.

Discussion

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion

Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals

Dmitrijs Celinskis, Nina Friedman, Mikhail Koksharov, et al.

Discussion

20 years of African Neuroscience: Waking a sleeping giant

MB Maina, U Ahmad, HA Ibrahim, et al.

Breaking the next Cryo-EM resolution barrier – Atomic resolution determination of proteins!

Ka Man Yip, Niels Fischer, Elham Paknia, et al.

Discussion

Physical constraints on early blastomere packings

James Giammona, Otger Campàs

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network

Joshua Hutchings, Viktoriya G. Stancheva, Nick R. Brown, et al.