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Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

Jayne Aiken, Erika L. F. Holzbaur

Selected by 04 December 2023

Matthew Davies

Cell Biology

Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion

Olivier Gemin, Maciej Gluc, Michael Purdy, et al.

Selected by 15 November 2023

Barbora Knotkova

Molecular Biology

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by 14 November 2023

Audrey Noireterre

Cancer Biology

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, et al.

Selected by 17 October 2023

Matheus Atella de Oliveira, Marcus Oliveira

Immunology

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, et al.

Selected by 16 October 2023

Matheus Atella de Oliveira, Marcus Oliveira

Biochemistry

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by 06 September 2023

Jessica Chevallier, Pierre Caron

Cell Biology

Proteasome condensate formation is driven by multivalent interactions with shuttle factors and K48-linked ubiquitin chains

Kenrick A. Waite, Gabrielle Vontz, Stella Y. Lee, et al.

Selected by 05 September 2023

Aniruddha Das

Biochemistry

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

Joshua Okletey, Dimitrios Angelis, Tia M. Jones, et al.

Selected by 31 July 2023

Megane Rayer

Cancer Biology

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Selected by 05 June 2023

Pierre Caron

Molecular Biology

Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages

Tatiana M. Clemente, Leonardo Augusto, Rajendra K. Angara, et al.

Selected by 16 May 2023

UofA IMB565

Microbiology

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

Selected by 15 May 2023

Jennifer Ann Black

Molecular Biology

Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

Agata Gluszek-Kustusz, Benjamin Craske, Thibault Legal, et al.

Selected by 06 May 2023

Divya Pathak, Barbora Knotkova

Cell Biology