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Kristina Kuhbandner

UT Southwestern Medical Center

“I am among those who think that science has great beauty. A scientist in his laboratory is not only a technician, he is also a child placed before natural phenomenon, which impress him like a fairy tale.”Mary Curie

This quote from Mary Curie expresses much what I am feeling about science. Every time I learn something new, I am fascinated again by the complexity and diversity of the world we are living in. My playground is located in the field of Neuroscience with special focus on translational research. Currently, I am investigating possible treatment strategies for amyotrophic lateral sclerosis at the Center for Translational Neurodegeneration Research at UT Southwestern Medical Center in Dallas. Next to Neuroscience, I also have a wide interest in other fields including immunology and molecular biology and I always enjoy spotting new discoveries and interesting stories to share with others.

Kristina Kuhbandner has added 16 preLight posts

Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels

Maria Elena De Obaldia, Takeshi Morita, Laura C. Dedmon, et al.



Selected by Kristina Kuhbandner

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FAIR enough? A perspective on the status of nucleotide sequence data and metadata on public archives

Christiane Hassenrück, Tobias Poprick, Véronique Helfer, et al.



Selected by Kristina Kuhbandner

1

Real-time visualization of mRNA synthesis during memory formation in live animals

Byung Hun Lee, Jae Youn Shim, Hyungseok C. Moon, et al.



Selected by Kristina Kuhbandner et al.

1

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

Constanze Depp, Ting Sun, Andrew Octavian Sasmita, et al.



Selected by Kristina Kuhbandner

1

Neuronal activity drives pathway-specific depolarization of astrocyte distal processes

Moritz Armbruster, Saptarnab Naskar, Jacqueline Garcia, et al.



Selected by Kristina Kuhbandner

1

Bioluminescent Genetically Encoded Glutamate Indicator for Molecular Imaging of Neuronal Activity

E. D. Petersen, E. L. Crespo, G. G. Lambert, et al.



Selected by Joanna Zell, Kristina Kuhbandner

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Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat

Andrew J. Stout, Addison B. Mirliani, Eugene C. White, et al.



Selected by Kristina Kuhbandner

Remembering immunity: Neuronal ensembles in the insular cortex encode and retrieve specific immune responses

Tamar Koren, Maria Krot, Nadia T. Boshnak, et al.



Selected by Kristina Kuhbandner

Cytostatic hypothermia and its impact on glioblastoma and survival

Syed Faaiz Enam, Cem Y. Kilic, Jianxi Huang, et al.



Selected by Kristina Kuhbandner

1

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, et al.



Selected by Kristina Kuhbandner

Investigating receptor-mediated antibody transcytosis using Blood-Brain Barrier organoid arrays

Claire Simonneau, Martina Duschmalé, Alina Gavrilov, et al.



Selected by Kristina Kuhbandner

1

Genetically-Modified Macrophages Accelerate Myelin Repair

Vanja Tepavčević, Gaelle Dufayet-Chaffaud, Marie-Stephane Aigrot, et al.



Selected by Kristina Kuhbandner

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Kristina Kuhbandner has commented 2 times

1 month

Kristina Kuhbandner

This preprint by De Obaldia and colleagues from the Vosshall lab was published in Cell (https://doi.org/10.1016/j.cell.2022.09.034) on 18 October 2022. Congratulations to all contributors!

The published version of the article did not undergo any substantial changes compared to the preprint posted on bioRxiv in January 2022. One obvious change is that the paragraphs and the associated figures (Figures 2 and 3 in the preprint) about the effect of Onco and Ir8a receptor mutations – both do not impair the ability of mosquitoes to differentiate individual humans – were summed up to make the results more concise. Furthermore, a section dealing with the “Limitations of the study” was added to the discussion. Here, the authors first point out that their findings do not demonstrate a direct causality between skin carboxylic acids and the attractiveness of individuals to mosquitoes. This would require evidence for necessity and sufficiency of these compounds which, at the moment, is extremely difficult to prove. Then, they emphasize that this study only focuses on compounds containing carboxylic acid groups; therefore, other chemical substances in human skin odor might play a role as well. Lastly, they mention that it remains unclear whether carboxylic acids or more volatile derivatives thereof are also involved in differential mosquito attraction to humans across long distances. The open questions raised in this preLight were not mentioned in this paragraph.

Overall, the implemented changes make the article even more concise, and I am excited to see how this work will contribute to the identification of mosquito magnets and the development of new intervention strategies to prevent the spread of pathogens caused by mosquitoes in the future.

2 years

Kristina Kuhbandner

Congratualations to the authors! I am very happy to see their work published in Brain this week.

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