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Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

Paolo Armando Gagliardi, Maciej Dobrzyński, Marc-Antoine Jacques, et al.

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

Alessandro Stirpe, Nora Guidotti, Sarah Northall, et al.

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, et al.

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Ruben Schep, Eva Brinkman, Christ Leemans, et al.

A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, et al.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, et al.

Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands

Kyle Swovick, Denis Firsanov, Kevin A. Welle, et al.

The antimicrobial peptide DGL13K is active against resistant gram-negative bacteria and subinhibitory concentrations stimulate bacterial growth without causing resistance

Sven-Ulrik Gorr, Hunter V. Brigman, Jadyn C. Anderson, et al.

Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

Megan K Oliva, Juan José Perez-Moreno, Jillian O’Shaughnessy, et al.

Temperature-Induced Uncoupling of Cell Cycle Regulators

Hanieh Falahati, Woonyung Hur, Stefano Di Talia, et al.

Subthreshold Voltage Analysis Demonstrates Neuronal Cell-Surface Sialic Acids Modulate Excitability and Network Integration

Rishikesh U. Kulkarni, Catherine L. Wang, Carolyn R. Bertozzi