I am a postdoc in the Bernstein lab at MGH/HMS in Boston where I study chromatin in cancer cells.
I did my Ph.D. on non-coding RNA in cancer in the lab of Chris Marine at the CCB (VIB-KU Leuven) in Belgium, and spent some time in the Steve Jackson Lab in Cambridge, UK, and the Misteli Lab at the NCI in Bethesda, USA during this time.
My scientific interests are non-coding RNA, nuclear bodies, mouse models & genetics, nuclear topology/chromatin conformation, phase separation, and gene expression/transcription. I’m most likely to post about these, but I am fascinated by many things in the biological world so it could be just as well any other random topic I really like or stumbled upon!
Apart from science, I love great food, contemporary dance, and people (I think everybody has a ‘thing’ and I like to discover that!).
KMT5C displays robust retention and liquid-like behavior in phase separated heterochromatin
Slide-seq: A Scalable Technology for Measuring Genome-Wide Expression at High Spatial Resolution
High-density spatial transcriptomics arrays for in situ tissue profiling
SorCS1-mediated Sorting of Neurexin in Dendrites Maintains Presynaptic Function
Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains
PUMILIO hyperactivity drives premature aging of Norad-deficient mice
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes
Nuclear pore density controls heterochromatin reorganization during senescence
SWI/SNF remains localized to chromatin in the presence of SCHLAP1
Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction
Hi Theo! Awesome highlight. I look forward to see higher resolution examples of this technique in the future, and I’m generally excited about non-genetic applications for DNA techniques!
As relating to the third paper you mention, you can take a look at this one, too: https://www.biorxiv.org/content/early/2018/08/02/383943