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I am an evolutionary cell biologist currently working as a Marie Sklodowska-Curie Fellow in Buzz Baum’s group at the MRC Lab for Molecular Cell Biology at UCL. I am interested in the evolution of the eukaryotic cell, and in particular the origins of the eukaryotic cell cycle. Overwhelming genomic evidence suggests that eukaryotes inherited the core of their cytoskeleton and cell division machinery from archaea, yet little is known about the function of their homologs in extant archaeal lineages. We are developing a live-imaging platform for a thermophilic archaeal model species, Sulfolobus, that has a eukaryote-like phasic cell cycle. In parallel, I am using our findings in archaea to predict and characterise potential novel, conserved roles for ancient cell division machines in the model unicellular eukaryote Schizosaccharomyces pombe.
I received my PhD from Stanford University’s Department of Chemical and Systems Biology in 2015, where I worked with Tobias Meyer on the evolution of human gene regulatory modules. Before moving to California, I worked with Satyajit Mayor and Mukund Thattai at the National Centre for Biological Sciences, Bangalore, India, on genome-scale screens for endocytosis in Drosophila.
Bridging the divide: bacteria synthesizing archaeal membrane lipids
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Extensive transfer of membrane lipid biosynthetic genes between Archaea and Bacteria
| Selected by | Gautam Dey |
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Revealing the nanoscale morphology of the primary cilium using super-resolution fluorescence microscopy
| Selected by | Gautam Dey |
Budding yeast complete DNA replication after chromosome segregation begins
| Selected by | Gautam Dey, Maiko Kitaoka |
Conserved phosphorylation hotspots in eukaryotic protein domain families
| Selected by | Gautam Dey |
Moving beyond P values: Everyday data analysis with estimation plots
| Selected by | Gautam Dey |
1
ER-to-Golgi trafficking of procollagen in the absence of large carriers.
| Selected by | Gautam Dey |
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Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction
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Quantitative imaging of chromatin decompaction in living cells
| Selected by | Carmen Adriaens, Gautam Dey |
Evidence that the cell cycle is a series of uncoupled, memoryless phases
| Selected by | Gautam Dey |
Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis
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Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment
| Selected by | Gautam Dey |
Nuclear envelope assembly defects link mitotic errors to chromothripsis
| Selected by | Gautam Dey |
Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms
| Selected by | Arnaud Monnard, Gautam Dey |