Gautam Dey, Author at preLights

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Preprint highlights, selected by the biological community

Gautam Dey

MRC Lab for Molecular Cell Biology, University College London

I am an evolutionary cell biologist currently working as a Marie Sklodowska-Curie Fellow in Buzz Baum’s group at the MRC Lab for Molecular Cell Biology at UCL. I am interested in the evolution of the eukaryotic cell, and in particular the origins of the eukaryotic cell cycle. Overwhelming genomic evidence suggests that eukaryotes inherited the core of their cytoskeleton and cell division machinery from archaea, yet little is known about the function of their homologs in extant archaeal lineages. We are developing a live-imaging platform for a thermophilic archaeal model species, Sulfolobus, that has a eukaryote-like phasic cell cycle. In parallel, I am using our findings in archaea to predict and characterise potential novel, conserved roles for ancient cell division machines in the model unicellular eukaryote Schizosaccharomyces pombe.

I received my PhD from Stanford University’s Department of Chemical and Systems Biology in 2015, where I worked with Tobias Meyer on the evolution of human gene regulatory modules. Before moving to California, I worked with Satyajit Mayor and Mukund Thattai at the National Centre for Biological Sciences, Bangalore, India, on genome-scale screens for endocytosis in Drosophila.

Gautam Dey has added 8 highlights

Conserved phosphorylation hotspots in eukaryotic protein domain families

Marta J Strumillo, Michaela Oplova, Cristina Vieitez, et al.

Moving beyond P values: Everyday data analysis with estimation plots

Joses Ho, Tayfun Tumkaya, Sameer Aryal, et al.

1

ER-to-Golgi trafficking of procollagen in the absence of large carriers.

Janine McCaughey, Nicola Stevenson, Stephen Cross, et al.

1

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

John K Eykelenboom, Marek Gierlinski, Zuojun Yue, et al.

AND

Quantitative imaging of chromatin decompaction in living cells

Elisa Dultz, Roberta Mancini, Guido Polles, et al.

Carmen Adriaens, Gautam Dey

Evidence that the cell cycle is a series of uncoupled, memoryless phases

Hui Xiao Chao, Randy I Fakhreddin, Hristo K Shimerov, et al.

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

Carlos Sacristan, Misbha Ahmad, Jenny Keller, et al.

AND

Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment

Cláudia Pereira, Rita M Reis, José B Gama, et al.

Nuclear envelope assembly defects link mitotic errors to chromothripsis

Shiwei Liu, Mijung Kwon, Mark Mannino, et al.

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

Tsung-li Liu, Srigokul Upadhyayula, Daniel E Milkie, et al.

Arnaud Monnard, Gautam Dey

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