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Gautam Dey

MRC Lab for Molecular Cell Biology, University College London

I am an evolutionary cell biologist currently working as a Marie Sklodowska-Curie Fellow in Buzz Baum’s group at the MRC Lab for Molecular Cell Biology at UCL. I am interested in the evolution of the eukaryotic cell, and in particular the origins of the eukaryotic cell cycle. Overwhelming genomic evidence suggests that eukaryotes inherited the core of their cytoskeleton and cell division machinery from archaea, yet little is known about the function of their homologs in extant archaeal lineages. We are developing a live-imaging platform for a thermophilic archaeal model species, Sulfolobus, that has a eukaryote-like phasic cell cycle. In parallel, I am using our findings in archaea to predict and characterise potential novel, conserved roles for ancient cell division machines in the model unicellular eukaryote Schizosaccharomyces pombe.

I received my PhD from Stanford University’s Department of Chemical and Systems Biology in 2015, where I worked with Tobias Meyer on the evolution of human gene regulatory modules. Before moving to California, I worked with Satyajit Mayor and Mukund Thattai at the National Centre for Biological Sciences, Bangalore, India, on genome-scale screens for endocytosis in Drosophila.

 

Gautam Dey has added 11 highlights

Bridging the divide: bacteria synthesizing archaeal membrane lipids

Laura Villanueva, F. A. Bastiaan von Meijenfeldt, Alexander B. Westbye, et al.

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Extensive transfer of membrane lipid biosynthetic genes between Archaea and Bacteria

Gareth A. Coleman, Richard D. Pancost, Tom A. Williams



Selected by Gautam Dey

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Revealing the nanoscale morphology of the primary cilium using super-resolution fluorescence microscopy

Joshua Yoon, Colin J. Comerci, Lucien E. Weiss, et al.



Selected by Gautam Dey

Budding yeast complete DNA replication after chromosome segregation begins

Tsvetomira Ivanova, Michael Maier, Alsu Missarova, et al.



Selected by Gautam Dey, Maiko Kitaoka

Conserved phosphorylation hotspots in eukaryotic protein domain families

Marta J Strumillo, Michaela Oplova, Cristina Vieitez, et al.



Selected by Gautam Dey

Moving beyond P values: Everyday data analysis with estimation plots

Joses Ho, Tayfun Tumkaya, Sameer Aryal, et al.



Selected by Gautam Dey

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ER-to-Golgi trafficking of procollagen in the absence of large carriers.

Janine McCaughey, Nicola Stevenson, Stephen Cross, et al.



Selected by Gautam Dey

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Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

John K Eykelenboom, Marek Gierlinski, Zuojun Yue, et al.

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Quantitative imaging of chromatin decompaction in living cells

Elisa Dultz, Roberta Mancini, Guido Polles, et al.



Selected by Carmen Adriaens, Gautam Dey

Evidence that the cell cycle is a series of uncoupled, memoryless phases

Hui Xiao Chao, Randy I Fakhreddin, Hristo K Shimerov, et al.



Selected by Gautam Dey

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

Carlos Sacristan, Misbha Ahmad, Jenny Keller, et al.

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Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment

Cláudia Pereira, Rita M Reis, José B Gama, et al.



Selected by Gautam Dey

Nuclear envelope assembly defects link mitotic errors to chromothripsis

Shiwei Liu, Mijung Kwon, Mark Mannino, et al.



Selected by Gautam Dey

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

Tsung-li Liu, Srigokul Upadhyayula, Daniel E Milkie, et al.



Selected by Arnaud Monnard, Gautam Dey

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