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Peer Review in Biomedical Sciences

Communication of scientific knowledge has changed dramatically in recent decades and the public perception of scientific discoveries depends on the peer review process of articles published in scientific journals. Preprints are key vehicles for the dissemination of scientific discoveries, but they are still not properly recognized by the scientific community since peer review is very limited. On the other hand, peer review is very heterogeneous and a fundamental aspect to improve it is to train young scientists on how to think critically and how to evaluate scientific knowledge in a professional way. Thus, this course aims to: i) train students on how to perform peer review of scientific manuscripts in a professional manner; ii) develop students' critical thinking; iii) contribute to the appreciation of preprints as important vehicles for the dissemination of scientific knowledge without restrictions; iv) contribute to the development of students' curricula, as their opinions will be published and indexed on the preLights platform. The evaluations will be based on qualitative analyses of the oral presentations of preprints in the field of biomedical sciences deposited in the bioRxiv server, of the critical reports written by the students, as well as of the participation of the students during the preprints discussions.

List by Marcus Oliveira, Mariana Ribeiro, Carmen Penido, clarissa maya-monteiro

Preprints:

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

Roxan A. Stephenson, Kory R. Johnson, Linling Cheng, Linda G. Yang, Jessica T. Root, Jaanam Gopalakrishnan, Han-Yu Shih, Priyanka S. Narayan

https://www.biorxiv.org/content/10.1101/2024.04.11.589145v1

Link to preLight: https://prelights.biologists.com/highlights/triglyceride-metabolism-controls-inflammation-and-apoe4-associated-disease-states-in-microglia/

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

Christa C. Huber, Eduardo Callegari, Maria Paez, Xiaoping Li, Hongmin Wang

https://www.biorxiv.org/content/10.1101/2024.02.09.579699v2

Link to preLight: https://prelights.biologists.com/highlights/impaired-26s-proteasome-causes-learning-and-memory-deficiency-and-induces-neuroinflammation-mediated-by-nf-%ce%bab-in-mice/

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kierveshan Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn

https://www.biorxiv.org/content/10.1101/2022.09.11.507472v1

Link to preLight: https://prelights.biologists.com/highlights/nadh-homeostasis-is-essential-for-host-protection-mediated-by-glycolytic-myeloid-cells-in-tuberculosis/

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, Isabell Beinborn, Nicole Paczia, Kristin Surmann, Sascha Blankenburg, Jochen Wilhelm, Javier Serrania, Kèvin Knoops, Eslam M. Elsayed, Katrin Laakmann, Anna Lena Jung, Andreas Kirschbaum, Mobarak Abu Mraheil, Anke Becker, Uwe Völker, Evelyn Vollmeister, Birke J. Benedikter, Bernd Schmeck

https://www.biorxiv.org/content/10.1101/2023.04.13.536709v1

Link to preLight: https://prelights.biologists.com/highlights/nad-metabolism-is-a-key-modulator-of-bacterial-respiratory-epithelial-infections/

Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells

Baoping Jiang, Liang Le, Keping Hu, Lijia Xu, Peigen Xiao

https://www.biorxiv.org/content/10.1101/176495v1

Link to preLight: https://prelights.biologists.com/highlights/metabolomic-profiling-reveals-effects-of-marein-on-energy-metabolism-in-hepg2-cells/

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

Juan Carlos Bórquez, Francisco Díaz-Castro, Francisco Pino-de La Fuente, Karla Espinoza, Ana María Figueroa, Inma Martínez-Ruíz, Vanessa Hernández, Iliana López-Soldado, Raúl Ventura, Alejandra Espinosa, Víctor Cortés, María Isabel Hernández-Alvarez, Rodrigo Troncoso

https://www.biorxiv.org/content/10.1101/2023.01.31.526481v1

Link to preLight: https://prelights.biologists.com/highlights/effects-of-aerobic-exercise-in-hepatic-lipid-droplet-mitochondria-interaction-in-non-alcoholic-fatty-liver-disease-v2/

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

Renata L.S. Goncalves, Zeqiu Branden Wang, Karen E. Inouye, Grace Yankun Lee, Xiaorong Fu, Jani Saksi, Clement Rosique, Gunes Parlakgul, Ana Paula Arruda, Sheng Tony Hui, Mar Coll Loperena, Shawn C. Burgess, Isabel Graupera, Gökhan S. Hotamisligil

https://www.biorxiv.org/content/10.1101/2023.02.21.528863v1

This preprint describes how hepatic glucose metabolism is impaired in obesity by demonstrating that reduced ubiquinone biosynthesis in liver mitochondria leads to RET and superoxide production which ultimately drives glucose intolerance. Understanding how hepatic glucose metabolism is affected by obesity is remarkable and sets the ground for the development of rational strategies to improve and overcome glucose intolerance in metabolic diseases.

Categories: biochemistry

 

Posted on: 27 February 2023 , updated on: 2 September 2024

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