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Keystone Symposium – Metabolic and Nutritional Control of Development and Cell Fate

This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.

List by Virginia Savy, Martin Estermann

Preprints:

Nutritional regulation of cellular quiescence depth and cell cycle re-entry in Vasa2+/Piwi1+ cells in a sea anemone

Eudald Pascual-Carreras, Kathrin Garschall, Patrick R.H. Steinmetz

https://www.biorxiv.org/content/10.1101/2025.02.27.640509v1

Presented by Patrick R.H. Steinmetz as a poster and as a short talk titled “Nutritional Regulation of Cellular Quiescence Depth In A Population Of Stem-Like Cells In A Sea Anemone” during the Metabolic Networks Defining Early Development session.

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions

Jessenya Mil, Jose A. Soto, Nedas Matulionis, Abigail Krall, Francesca Day, Linsey Stiles, Katrina P. Montales, Daria J. Azizad, Carlos E. Gonzalez, Patricia R. Nano, Antoni A. Martija, Cesar A. Perez-Ramirez, Claudia V. Nguyen, Ryan L. Kan, Madeline G. Andrews, Heather R. Christofk, Aparna Bhaduri

https://www.biorxiv.org/content/10.1101/2025.03.10.642470v1

Presented by Jose A. Soto as a poster and a short talk titled “Metabolic Atlas of Early Human Cortical Development”  during the Symposia Spotlight: Redox Control of Developmental Pathways.

The fate of pyruvate dictates cell growth by modulating cellular redox potential

Ashish G. Toshniwal, Geanette Lam, Alex J. Bott, Ahmad A. Cluntun, Rachel Skabelund, Hyuck-Jin Nam, Dona R. Wisidagama, Carl S. Thummel, Jared Rutter

https://www.biorxiv.org/content/10.1101/2024.09.23.614588v1

Presented by Ashish G. Toshniwal as a poster and as a short talk titled “The Fate of Pyruvate: Metabolic regulation of Cell Growth” during the Nutritional Influences on Development session.

TCA cycle rewiring underpins implantation and histone acetylation programming

Eleni Kafkia, David Pladevall-Morera, Lidia Argemi-Muntadas, Gangqi Wang, Roberta Noberini, Sandra Bagés-Arnal, Matthias Anagho-Mattanovich, Rita Silvério-Alves, Tiziana Bonaldi, Ton J. Rabelink, Thomas Moritz, Jan Jakub Żylicz

https://www.biorxiv.org/content/10.1101/2025.04.25.650409v1

Presented by Eleni Kafkia as a poster and a short talk titled “TCA Rewiring Underpins Implantation and Histone Acetylation Programming” during the Metabolic Networks Defining Early Development session.

Polyamines regulate cell fate by altering the activity of histone-modifying enzymes

Maya Emmons-Bell, Grace Forsyth, Abby Sundquist, Sylvie Oldeman, Angeliki Gardikioti, Roshni de Souza, Jonathan Coene, Maryam H. Kamel, Shine Ayyapan, Harrison A. Fuchs, Steven Verhelst, Joanna Smeeton, Catherine A. Musselman, Juan-Manuel Schvartzman

https://www.biorxiv.org/content/10.1101/2024.07.02.600738v1

Presented by Juan Manuel Schvartzman as a short talk titled “Polyamines Regulate Cell Fate by Altering the Accessibility of Histone Tails” during the Metabolic Control of Cell Fate session.

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, Ashley Rowe, Hetali Trivedi, Brandon Faubert, Zheng Wu, Jessica Sudderth, Lauren G. Zacharias, Bushra Afroze, Ilya Bezprozvanny, Sunil Sudarshan, Feng Cai, Samuel K. McBrayer, Thomas P. Mathews, Ralph J. DeBerardinis

https://www.biorxiv.org/content/10.1101/2025.04.16.649033v1

Presented by Ralph DeBerardinis as a talk titled “Fixed Metabolic Defects and their Developmental Consequences” during the Gene-Environment Interactions in Development session.

Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA

Virginia Savy, Paula Stein, Don Delker, Martín A. Estermann, Brian N. Papas, Zongli Xu, Lenka Radonova, Carmen J. Williams

https://www.biorxiv.org/content/10.1101/2025.03.14.643362v1

Presented by Virginia Savy as a Poster titled “Metabolic regulation of epigenetic reprogramming at fertilization”

A mitochondrial redox switch licenses the onset of morphogenesis in animals

Updip Kahlon, Francesco Dalla Ricca, Saraswathi J. Pillai, Marine Olivetta, Kevin M. Tharp, Li-En Jao, Omaya Dudin, Kent McDonald, Mustafa G. Aydogan

https://www.biorxiv.org/content/10.1101/2024.10.28.620733v1

Presented by Francesco Dalla Ricca as a poster and as a short talk titled “A Mitochondrial Redox Switch Licenses the Onset of Morphogenesis in Animals”  during the Symposia Spotlight: Redox Control of Developmental Pathways.

A noncanonical polyamine from bacteria antagonizes animal mitochondrial function

Kelsie M. Nauta, Darrick R. Gates, Matthew Weiland, Marco E. Mechan-Llontop, Xiao Wang, Kim P. Nguyen, Christine Isaguirre, Megan R. Genjdar, Ryan D. Sheldon, Connie M. Krawczyk, Nicholas O. Burton

https://www.biorxiv.org/content/10.1101/2024.04.29.591726v2

Presented by Nick Burton as a poster and as a short talk titled “Microbial Metabolism of Polyamines and Pyruvate Regulate Animal Development” during the Nutritional Influences on Development session.

Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition

Shruthi Krishnan, Ana Lima, Ying Thong Low, Salvador Perez Montero, Sizhe Tan, Aida Di Gregorio, Adrian Perez Barreto, Sarah Bowling, Karen Vousden, Tristan A. Rodriguez

https://www.biorxiv.org/content/10.1101/2024.11.28.625863v1

Presented by Tristan A. Rodriguez as a talk “Nutrient Regulation of Cell Fitness and Patterning in the Early Mammalian Embryo” during the Metabolic Networks Defining Early Development session.

Glycolysis–Wnt signaling axis tunes developmental timing of embryo segmentation

Hidenobu Miyazawa, Jona Rada, Paul Gerald Layague Sanchez, Emilia Esposito, Daria Bunina, Charles Girardot, Judith Zaugg, Alexander Aulehla

https://www.biorxiv.org/content/10.1101/2024.01.22.576629v2

Presented by Hidenobu Miyazawa as a poster titled “Dissociating the signaling and metabolic functions of glycolysis in mouse embryos” during the poster session

Categories: biochemistry , bioinformatics , cancer biology , cell biology , developmental biology , genetics , molecular biology

Tags: development , epigenetic , keystone , metabolism

Posted on: 14 May 2025 , updated on: 25 May 2025

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A list of the preprints featured in Development's 'In preprints' articles between 2022-2023

 



List by Alex Eve, Katherine Brown

preLights peer support – preprints of interest

This is a preprint repository to organise the preprints and preLights covered through the 'preLights peer support' initiative.

 



List by preLights peer support

The Society for Developmental Biology 82nd Annual Meeting

This preList is made up of the preprints discussed during the Society for Developmental Biology 82nd Annual Meeting that took place in Chicago in July 2023.

 



List by Joyce Yu, Katherine Brown

CSHL 87th Symposium: Stem Cells

Preprints mentioned by speakers at the #CSHLsymp23

 



List by Alex Eve

Journal of Cell Science meeting ‘Imaging Cell Dynamics’

This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.

 



List by Helen Zenner

9th International Symposium on the Biology of Vertebrate Sex Determination

This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.

 



List by Martin Estermann

Alumni picks – preLights 5th Birthday

This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.

 



List by Sergio Menchero et al.

CellBio 2022 – An ASCB/EMBO Meeting

This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.

 



List by Nadja Hümpfer et al.

2nd Conference of the Visegrád Group Society for Developmental Biology

Preprints from the 2nd Conference of the Visegrád Group Society for Developmental Biology (2-5 September, 2021, Szeged, Hungary)

 



List by Nándor Lipták

Fibroblasts

The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!

 



List by Osvaldo Contreras

EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)

A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.

 



List by Alex Eve

EMBL Conference: From functional genomics to systems biology

Preprints presented at the virtual EMBL conference "from functional genomics and systems biology", 16-19 November 2020

 



List by Jesus Victorino

Single Cell Biology 2020

A list of preprints mentioned at the Wellcome Genome Campus Single Cell Biology 2020 meeting.

 



List by Alex Eve

Society for Developmental Biology 79th Annual Meeting

Preprints at SDB 2020

 



List by Irepan Salvador-Martinez, Martin Estermann

FENS 2020

A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020

 



List by Ana Dorrego-Rivas

Planar Cell Polarity – PCP

This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.

 



List by Ana Dorrego-Rivas

Cell Polarity

Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.

 



List by Yamini Ravichandran

TAGC 2020

Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

 



List by Maiko Kitaoka et al.

3D Gastruloids

A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells). Updated until July 2021.

 



List by Paul Gerald L. Sanchez and Stefano Vianello

ASCB EMBO Annual Meeting 2019

A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

 



List by Madhuja Samaddar et al.

EDBC Alicante 2019

Preprints presented at the European Developmental Biology Congress (EDBC) in Alicante, October 23-26 2019.

 



List by Sergio Menchero et al.

EMBL Seeing is Believing – Imaging the Molecular Processes of Life

Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

 



List by Dey Lab

SDB 78th Annual Meeting 2019

A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.

 



List by Alex Eve

Lung Disease and Regeneration

This preprint list compiles highlights from the field of lung biology.

 



List by Rob Hynds

Young Embryologist Network Conference 2019

Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London

 



List by Alex Eve

Pattern formation during development

The aim of this preList is to integrate results about the mechanisms that govern patterning during development, from genes implicated in the processes to theoritical models of pattern formation in nature.

 



List by Alexa Sadier

BSCB/BSDB Annual Meeting 2019

Preprints presented at the BSCB/BSDB Annual Meeting 2019

 



List by Dey Lab

Zebrafish immunology

A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.

 



List by Shikha Nayar

Also in the genetics category:

May in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) Biochemistry/metabolism 2) Cancer cell Biology 3) Cell adhesion, migration and cytoskeleton 4) Cell organelles and organisation 5) Cell signalling and 6) Genetics

 



List by Barbora Knotkova et al.

Keystone Symposium – Metabolic and Nutritional Control of Development and Cell Fate

This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.

 



List by Virginia Savy, Martin Estermann

April in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics

 



List by Vibha SINGH et al.

March in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) cancer biology 2) cell migration 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) genetics and genomics 6) other

 



List by Girish Kale et al.

Biologists @ 100 conference preList

This preList aims to capture all preprints being discussed at the Biologists @100 conference in Liverpool, UK, either as part of the poster sessions or the (flash/short/full-length) talks.

 



List by Reinier Prosee, Jonathan Townson

Early 2025 preprints – the genetics & genomics edition

In this community-driven preList, a group of preLighters, with expertise in different areas of genetics and genomics have worked together to create this preprint reading list. Categories include: 1) bioinformatics 2) epigenetics 3) gene regulation 4) genomics 5) transcriptomics

 



List by Chee Kiang Ewe et al.

January in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell migration 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) genetics/gene expression

 



List by Barbora Knotkova et al.

End-of-year preprints – the genetics & genomics edition

In this community-driven preList, a group of preLighters, with expertise in different areas of genetics and genomics have worked together to create this preprint reading list. Categories include: 1) genomics 2) bioinformatics 3) gene regulation 4) epigenetics

 



List by Chee Kiang Ewe et al.

BSDB/GenSoc Spring Meeting 2024

A list of preprints highlighted at the British Society for Developmental Biology and Genetics Society joint Spring meeting 2024 at Warwick, UK.

 



List by Joyce Yu, Katherine Brown

BSCB-Biochemical Society 2024 Cell Migration meeting

This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.

 



List by Reinier Prosee

9th International Symposium on the Biology of Vertebrate Sex Determination

This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.

 



List by Martin Estermann

Alumni picks – preLights 5th Birthday

This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.

 



List by Sergio Menchero et al.

Semmelweis Symposium 2022: 40th anniversary of international medical education at Semmelweis University

This preList contains preprints discussed during the 'Semmelweis Symposium 2022' (7-9 November), organised around the 40th anniversary of international medical education at Semmelweis University covering a wide range of topics.

 



List by Nándor Lipták

20th “Genetics Workshops in Hungary”, Szeged (25th, September)

In this annual conference, Hungarian geneticists, biochemists and biotechnologists presented their works. Link: http://group.szbk.u-szeged.hu/minikonf/archive/prg2021.pdf

 



List by Nándor Lipták

2nd Conference of the Visegrád Group Society for Developmental Biology

Preprints from the 2nd Conference of the Visegrád Group Society for Developmental Biology (2-5 September, 2021, Szeged, Hungary)

 



List by Nándor Lipták

EMBL Conference: From functional genomics to systems biology

Preprints presented at the virtual EMBL conference "from functional genomics and systems biology", 16-19 November 2020

 



List by Jesus Victorino

TAGC 2020

Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

 



List by Maiko Kitaoka et al.

ECFG15 – Fungal biology

Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome

 



List by Hiral Shah

Autophagy

Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

 



List by Sandra Malmgren Hill

Also in the molecular biology category:

May in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) Biochemistry/metabolism 2) Cancer cell Biology 3) Cell adhesion, migration and cytoskeleton 4) Cell organelles and organisation 5) Cell signalling and 6) Genetics

 



List by Barbora Knotkova et al.

Keystone Symposium – Metabolic and Nutritional Control of Development and Cell Fate

This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.

 



List by Virginia Savy, Martin Estermann

April in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics

 



List by Vibha SINGH et al.

Biologists @ 100 conference preList

This preList aims to capture all preprints being discussed at the Biologists @100 conference in Liverpool, UK, either as part of the poster sessions or the (flash/short/full-length) talks.

 



List by Reinier Prosee, Jonathan Townson

February in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry and cell metabolism 2) cell organelles and organisation 3) cell signalling, migration and mechanosensing

 



List by Barbora Knotkova et al.

Community-driven preList – Immunology

In this community-driven preList, a group of preLighters, with expertise in different areas of immunology have worked together to create this preprint reading list.

 



List by Felipe Del Valle Batalla et al.

January in preprints – the CellBio edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell migration 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) genetics/gene expression

 



List by Barbora Knotkova et al.

2024 Hypothalamus GRC

This 2024 Hypothalamus GRC (Gordon Research Conference) preList offers an overview of cutting-edge research focused on the hypothalamus, a critical brain region involved in regulating homeostasis, behavior, and neuroendocrine functions. The studies included cover a range of topics, including neural circuits, molecular mechanisms, and the role of the hypothalamus in health and disease. This collection highlights some of the latest advances in understanding hypothalamic function, with potential implications for treating disorders such as obesity, stress, and metabolic diseases.

 



List by Nathalie Krauth

BSCB-Biochemical Society 2024 Cell Migration meeting

This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.

 



List by Reinier Prosee

‘In preprints’ from Development 2022-2023

A list of the preprints featured in Development's 'In preprints' articles between 2022-2023

 



List by Alex Eve, Katherine Brown

CSHL 87th Symposium: Stem Cells

Preprints mentioned by speakers at the #CSHLsymp23

 



List by Alex Eve

9th International Symposium on the Biology of Vertebrate Sex Determination

This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.

 



List by Martin Estermann

Alumni picks – preLights 5th Birthday

This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.

 



List by Sergio Menchero et al.

CellBio 2022 – An ASCB/EMBO Meeting

This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.

 



List by Nadja Hümpfer et al.

EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)

A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.

 



List by Alex Eve

FENS 2020

A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020

 



List by Ana Dorrego-Rivas

ECFG15 – Fungal biology

Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome

 



List by Hiral Shah

ASCB EMBO Annual Meeting 2019

A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

 



List by Madhuja Samaddar et al.

Lung Disease and Regeneration

This preprint list compiles highlights from the field of lung biology.

 



List by Rob Hynds

MitoList

This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.

 



List by Sandra Franco Iborra

Also in the biochemistry category:

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis

Madeleine L. Hart, Kristian Davidsen, Serwah Danquah, et al.

Selected by 26 May 2025

Hannah Pletcher

Cancer Biology

Chronic stress antagonizes formation of Stress Granules

Yuichiro Adachi, Allison M. Williams, Masashi Masuda, et al.

Selected by 08 April 2025

Mohammed JALLOH

Cell Biology

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, et al.

Selected by 13 February 2025

Roberto Amadio

Biochemistry

Also in the bioinformatics category:

STEAMBOAT: Attention-based multiscale delineation of cellular interactions in tissues

Shaoheng Liang, Junjie Tang, Guanghan Wang, et al.

Selected by 25 April 2025

Benjamin Dominik Maier

Bioinformatics

Decoding the Molecular Language of Proteins with Evolla

Xibin Zhou, Chenchen Han, Yingqi Zhang, et al.

Selected by 14 March 2025

Jawdat Sandakly

Bioinformatics

Tidyplots empowers life scientists with easy code-based data visualization

Jan Broder Engler

Selected by 21 February 2025

Felipe Del Valle Batalla

Bioinformatics

Also in the cancer biology category:

Tumoral CD24 tunes platelet binding and pro-metastatic functions

Vincent Mittelheisser, Cristina Liboni, Clarisse Mouriaux, et al.

Selected by 16 June 2025

Harvey Roweth

Cancer Biology

Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion

Aashrith Saraswathibhatla, Md Foysal Rabbi, Sushama Varma, et al.

Selected by 10 June 2025

Sharvari Pitke

Biophysics

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Veronica Cherdyntseva, Joanna Paulson, Selin Adakli, et al.

Selected by 05 June 2025

Jenny Singh

Molecular Biology

Also in the cell biology category:

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis

Madeleine L. Hart, Kristian Davidsen, Serwah Danquah, et al.

Selected by 26 May 2025

Hannah Pletcher

Cancer Biology

Early resident NK cell response to local HIV infection in lymphoid tissue

David Perea, Alba Gonzalez, Nerea Sanchez-Gaona, et al.

Selected by 19 May 2025

Sukirti Shivpuri et al.

Immunology

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

Jens Bager Christensen, Alex P.A. Donovan, Marzieh Moradi, et al.

Selected by 15 May 2025

Jethro Lundie-Brown

Developmental Biology

Also in the developmental biology category:

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

Giulia Allavena, Francesca Rossiello, Aurora Irene Idilli, et al.

Selected by 13 June 2025

Jawdat Sandakly

Developmental Biology

Mechanical fracturing of the extracellular matrix patterns the vertebrate heart

Christopher Chan Jin Jie, Daniel Santos-Oliván, Marie-Christine Ramel, et al.

Selected by 06 June 2025

Theodora Stougiannou

Developmental Biology

3D mechanical confinement directs muscle stem cell fate and function

GaYoung Park, Josh A. Grey, Foteini Mourkioti, et al.

Selected by 30 April 2025

Justin Gutkowski

Bioengineering

Also in the genetics category:

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

Giulia Allavena, Francesca Rossiello, Aurora Irene Idilli, et al.

Selected by 13 June 2025

Jawdat Sandakly

Developmental Biology

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Veronica Cherdyntseva, Joanna Paulson, Selin Adakli, et al.

Selected by 05 June 2025

Jenny Singh

Molecular Biology

Direct cell-to-cell transmission of retrotransposons

Maya Voichek, Andreas Bernhard, Maria Novatchkova, et al.

Selected by 21 May 2025

Ally Simpson et al.

Genetics

Also in the molecular biology category:

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Veronica Cherdyntseva, Joanna Paulson, Selin Adakli, et al.

Selected by 05 June 2025

Jenny Singh

Molecular Biology

Cortical astrocyte activation triggers meningeal nociception and migraine-like pain

Dara Bree, Jun Zhao, Jennifer Stratton, et al.

Selected by 19 May 2025

Vanessa Ehlers

Neuroscience

tRNA synthetase activity is required for stress granule and P-body assembly

Max Baymiller, Noah S. Helton, Benjamin Dodd, et al.

Selected by 19 May 2025

Mohammed JALLOH

Molecular Biology