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2024 Hypothalamus GRC

This 2024 Hypothalamus GRC (Gordon Research Conference) preList offers an overview of cutting-edge research focused on the hypothalamus, a critical brain region involved in regulating homeostasis, behavior, and neuroendocrine functions. The studies included cover a range of topics, including neural circuits, molecular mechanisms, and the role of the hypothalamus in health and disease. This collection highlights some of the latest advances in understanding hypothalamic function, with potential implications for treating disorders such as obesity, stress, and metabolic diseases.

List by Nathalie Krauth

Preprints:

Thermally-induced neuronal plasticity that mediates heat tolerance

Wojciech Ambroziak, Sara Nencini, Jörg Pohle, Kristina Zuza, Gabriela Pino, Sofia Lundh, Carolina Araujo-Sousa, Larissa I. L. Goetz, Katrin Schrenk-Siemens, Gokul Manoj, Mildred A. Herrera, Claudio Acuna, Jan Siemens

https://www.biorxiv.org/content/10.1101/2024.08.06.606929v1

Presented by Jan Siemens in the  Hypothalamic Control of Temperature and Metabolic States session.

Prolonged activation of EP3 receptor-expressing preoptic neurons underlies torpor responses

Natalia Machado, Francesca Raffin, Satvinder Kaur, Alexander Banks, Nicole Lynch, Oleksandra Fanari, Oscar Plascencia, Sydney Aten, Janayna Lima, Sathyajit Bandaru, Richard Palmiter, Elda Arrigoni, Clifford Saper

https://www.researchsquare.com/article/rs-2861253/v1

Presented by Natalie Machado in the Hypothalamic Control of Temperature and Metabolic States session.

A Hypothalamic Circuit that Modulates Feeding and Parenting Behaviors

Ivan C. Alcantara, Chia Li, Laura E. Mickelsen, Christopher M. Mazzone, Isabel de Araujo Salgado, Claire Gao, Brian N. Papas, Cuiying Xiao, Eva O. Karolczak, Abigail I. Goldschmidt, Shakira Rodriguez Gonzalez, Ramón A. Piñol, Jian-Liang Li, Guohong Cui, Marc L. Reitman, Michael J. Krashes

https://www.biorxiv.org/content/10.1101/2024.07.22.604437v1

Presented by Ivan Alcantara in the Competing Demands and Motivations session.

Generation of human appetite-regulating neurons and tanycytes from stem cells

Zehra Abay-Nørgaard, Anika K Müller, Erno Hänninen, Dylan Rausch, Louise Piilgaard, Jens Bager Christensen, Sofie Peeters, Alrik L. Schörling, Alison Salvador, Viktoriia Nikulina, Yuan Li, Janko Kajtez, Tune H Pers, Agnete Kirkeby

https://www.biorxiv.org/content/10.1101/2024.07.11.603039v1

Presented by Anika Mueller in the poster session.

Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

Addison N. Webster, Jordan J. Becker, Chia Li, Dana C. Schwalbe, Damien Kerspern, Eva O. Karolczak, Catherine Bundon, Roberta A. Onoharigho, Maisie Crook, Maira Jalil, Elizabeth N. Godschall, Emily G. Dame, Adam Dawer, Dylan Matthew Belmont-Rausch, Tune H. Pers, Andrew Lutas, Naomi Habib, Ali D. Güler, Michael J. Krashes, John N. Campbell

https://www.biorxiv.org/content/10.1101/2023.10.31.564990v2

Presented by Addison Webster in the poster session.

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Travis D. Goode, Jason Bondoc Alipio, Antoine Besnard, Devesh Pathak, Michael D. Kritzer-Cheren, Ain Chung, Xin Duan, Amar Sahay

https://www.biorxiv.org/content/10.1101/2024.08.02.606427v1

Presented by Travis Goode in the Hypothalamus GRS.

A Normative Framework Dissociates Need and Motivation in Hypothalamic Neurons

Kyu Sik Kim, Young Hee Lee, Yu-Been Kim, Jong Won Yun, Ha Young Song, Joon Seok Park, Sang-Ho Jung, Jong-Woo Sohn, Ki Woo Kim, HyungGoo R. Kim, Hyung Jin Choi

https://www.biorxiv.org/content/10.1101/2023.10.01.560411v2

Presented by Hyung Jin Choi in the Competing Demands and Motivations session.

Anatomically distributed neural representations of instincts in the hypothalamus

Stefanos Stagkourakis, Giada Spigolon, Markus Marks, Michael Feyder, Joseph Kim, Pietro Perona, Marius Pachitariu, David J. Anderson

https://www.biorxiv.org/content/10.1101/2023.11.21.568163v2

Presented by Stefanos Stagkourakis in the Competing Demands and Motivations session.

Direct modulation of CRH nerve terminal function by noradrenaline and corticosterone

Emmet M. Power, Dharshini Ganeshan, Jamieson Paul, Hiroyuki Igarashi, Wataru Inoue, Karl J. Iremonger

https://www.biorxiv.org/content/10.1101/2024.06.11.598540v1

Presented by Karl Iremonger in the Hypothalamic Regulation of Physiology and Behavior session.

A parabrachial hub for the prioritization of survival behavior

Nitsan Goldstein, Amadeus Maes, Heather N. Allen, Tyler S. Nelson, Kayla A. Kruger, Morgan Kindel, Nicholas K. Smith, Jamie R.E. Carty, Rachael E. Villari, Ella Cho, Erin L. Marble, Rajesh Khanna, Bradley K. Taylor, Ann Kennedy, J. Nicholas Betley

https://www.biorxiv.org/content/10.1101/2024.02.26.582069v1

Presented by J Nicholas Betley in the Competing Demands and Motivations session.

A hypothalamus-brainstem circuit governs the prioritization of safety over essential needs

Nathalie Krauth, Lara Sach, Christoffer Clemmensen, Ole Kiehn

https://www.biorxiv.org/content/10.1101/2024.09.05.611412v1

Presented by Nathalie Krauth in the poster session.

Categories: molecular biology , neuroscience , systems biology

Tags: brain , hypothalamus , metabolism , parenting , stress , temperature

Posted on: 6 September 2024 , updated on: 10 September 2024

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