Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma
Posted on: 13 August 2026
Preprint posted on 25 December 2025
Bad company: how microglial function is corrupted in diffuse midline glioma, to promote pathogenic neuronal hyperexcitability.
Selected by CRM UoE Journal Club
Categories: cancer biology, immunology, neuroscience, pathology
This preLight was prepared by Alsadeg Bilal, Mary Lorino, and Sophie Brumm, members of the Centre for Regenerative Medicine (CRM) Journal Club at The University of Edinburgh
Background
Diffuse midline glioma (DMG) is a lethal form of paediatric brain cancer, arising from the midline structures such as the pons, the brainstem and the thalamus. The median survival is under 12 months, and this has remained largely unchanged for decades (Jovanovich et al., 2023). Patients typically present with progressive neurological deficits related to tumour location, such as cranial nerve palsy, ataxia, and seizures. These features contribute substantially to morbidity, loss of independence and a reduced quality of life.
DMG is understood as a neurodevelopmental circuit integrated tumour. It transcriptionally resembles oligodendrocyte precursor cells, a population whose proliferation and differentiation are regulated by neuronal activity. This developmental context is important because neuronal activity also promotes glioma progression. Activity-regulated release of paracrine factors, including neuroligin-3, and the formation of bona fide neuron-to-glioma synapses create a feed-forward loop in which active neural circuits promote tumour growth, while tumour cells increase neuronal excitability (Venkatesh et al., 2015).
The observed hyperexcitability reflects a disrupted excitatory-to-inhibitory (E:I) balance in the brain. Previous work has shown that glioma cells receive functional glutamatergic synaptic inputs, and more recent work has identified tumour-promoting GABAergic neuron-to-glioma synapses in DMG (Venkataramani et al., 2019; Barron et al., 2025). Recent work has therefore focused on a self-amplifying feedback loop, in which neuronal activity promotes glioma growth through secreted synaptogenic or mitogenic factors and direct synaptic integration, while glioma cells further increase neuronal excitability (Venkatesh et al., 2015; Venkataramani et al., 2019; Taylor et al., 2023).
Mancusi et al. highlight that the contribution of microglia in the regulation of neuron-to-glioma synapses is understudied. In the healthy brain, microglia can refine neural circuits by surveying synapses and engulfing complement-tagged synaptic material (Schafer et al., 2012; Soteros et al., 2021). This process, often referred to as synaptic pruning, helps remove inappropriate or excessive connections. Microglia engage with synapses in an activity-dependent manner and therefore play a vital role in maintaining circuit homeostasis (Schafer et al., 2012).
The authors set out to study whether microglial function is altered in a DMG context, which may contribute to the skewed E:I balance. Their observations suggest that healthy microglial pruning mechanisms are reversed in DMG, to promote excitatory over inhibitory synapses in an activity-dependent manner.
Key findings
DMG shifts microglial engulfment away from excitatory synapses and towards inhibitory synaptic material
The authors first sought to compare microglia engulfment of excitatory and inhibitory synapses in xenograft mouse models. In this experiment, patient-derived DMG cells or buffered saline (nontumor control) were delivered to the frontal cortex of immunocompromised NSG mice. Their analysis indicated that in the DMG model, microglia exhibited increased engulfment of both inhibitory and excitatory synapses, compared to the nontumor control. The authors further observed that when the tumour burden was increased, microglia began to engulf fewer excitatory synapses, whereas engulfment of inhibitory synapses remained unchanged. These observations suggest that microglia modulate the E:I balance in DMG.
Acute circuit activity is no longer dampened in a DMG context
The authors next assessed whether the synaptic engulfment by microglia was activity dependent. In nontumor control mice, optogenetic stimulation of deep layer cortical projection neurons resulted in significantly more engulfment of excitatory synapses, i.e. a dampening of the acutely stimulated neuronal circuits. This control experiment thereby revealed a previously underappreciated negative feedback mechanism that maintains homeostatic circuit excitability. In a DMG context, however, acute optogenetic stimulation had the opposite effect, where microglia preferentially engulfed inhibitory synapses, resulting in a skewed E:I balance. These results further support microglia’s role of regulating the E:I balance in DMG, with input from surrounding neuronal circuits.
DMG-carrying mice display signs of neural hyperexcitability
The authors employed a second mouse model, to study the DMG microenvironment in a fully immunocompetent context. In this model, murine glioma cells were introduced into syngeneic hosts, allowing the authors to examine tumour-microglia-neuron interactions without the limitations of severe immunodeficiency. Optogenetic stimulation was used to probe how tumour-bearing circuits respond to increased neural activity. This allograft model corroborated neuronal hyperexcitability in DMG through higher postsynaptic potentials and increased frequency of spontaneous excitatory postsynaptic currents, while inhibitory postsynaptic currents were unchanged.
Healthy circuitry dampening mechanisms are reversed in a DMG context
To better understand the transcriptomic changes associated with DMG, the authors performed optogenetic stimulation in the allograft model. Optogenic stimulation triggered glutamatergic cortical activity, to mimic increased neural activity in DMG.
sn-RNAseq revealed an increase in complement-associated microglial subpopulations in response to glutamatergic neuronal activity in nontumor control mice, as is critical for excitatory circuit pruning. This complement pathway activation of microglia was downregulated in a DMG context, suggesting that microglia can no longer respond to the increased neuronal activity in the tumour microenvironment.
Neuronal activity exacerbates the impact of DMG tumour cells on microglia phenotype
Following the analysis of in vivo models, the authors turned to functionally in vitro experiments to distinguish between the impact of DMG tumour cells and neural activity alone on microglial engulfment. The authors exposed co-cultures of healthy human microglia-like cells, GABAergic and glutamatergic neurons to conditioned media from DMG- or healthy mouse brain slice cultures, following exogenous activation or unstimulated control. This experiment elegantly tests for the presence of secreted factors, which modulate microglia activity regardless of cell contact with DMG tumour cells.
The authors first noted that in the nontumor control setting, stimulation of neuronal activity released secreted factors, which resulted in microglial engulfment of excitatory synapses. This in vitro observation corroborates the in vivo dampening of acute circuit activity observed in their mouse model.
By contrast, unstimulated DMG-conditioned media promoted a tumour-associated microglial phenotype and impaired normal synaptic engulfment function. Conditioned media from stimulated DMG-bearing slices further exacerbated this effect, reducing microglial engulfment of excitatory synapses and shifting microglia away from their homeostatic circuit-dampening role.
Overall, the authors present data supporting a model in which microglia in DMG-impacted brains contribute to a self-amplifying loop of neuronal hyperexcitability. In healthy tissue, activity-dependent microglial pruning helps restrain excessive excitation. In DMG, this mechanism is corrupted: microglia fail to appropriately prune excitatory synaptic material and may instead preferentially remove inhibitory synaptic elements. This shifts the E:I balance towards excitation, strengthening the neuronal activity state that supports glioma growth.
Why we highlight this preprint
Mancusi et al. demonstrate the strength of integrating multiple in vitro and in vivo models to disentangle complex problems, such as presented by the DMG microenvironment. Their work highlights the importance of taking all cellular players into account when studying and treating the tumour microenvironment. The presented paper offers new research avenues into the secreted factors, which modulate microglia function, that have the potential to impact patient quality of life and treatment outcome.
Questions and suggestions for the authors
- The most pressing issue is the identity of the factors, which are secreted in DMG-diseased brains, which modulate microglial behaviour. Once identified, druggable targets may emerge which offer additional therapeutic angles.
- Could the authors describe their plans to identify the key modulating factors, or perhaps share which candidate molecules they may suspect?
- Have the authors considered a brainstem model, as described in https://doi.org/10.1093/noajnl/vdac079, to complement their work?
Sign up to customise the site to your preferences and to receive alerts
Register hereAlso in the cancer biology category:
Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer
Akshata Samel
Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling
Zoha Sadaqat
A pre-rRNA positive feedback loop drives malignant ribosome biogenesis
Vaishali Grewal
Also in the immunology category:
Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma
CRM UoE Journal Club
Circadian Clock Programming of Anticipatory Antiviral Immunity Gates Enteric Virus Infection Susceptibility
Owen Ang
Inhibition of VP2-mediated entry: a potential antiviral strategy to treat or prevent calicivirus disease
Orestis Savva
Also in the neuroscience category:
Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma
CRM UoE Journal Club
Diversity and Spatial Segregation of TRP Channels in Choanoflagellates Provide Insight into the Evolutionary Origin of Animal Sensory Systems
Urvashi Goswami
Behavioral characteristics of an extremely old rhesus macaque in a zoo: Dementia-like symptoms and implications for quality of life of geriatric animals
Stefan Friedrich Wirth
Also in the pathology category:
Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma
CRM UoE Journal Club
EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis
Léa Bastien et al.
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367,988 people using natural language processing
Rafidah Mumtahinah Chowdhury et al.
preLists in the cancer biology category:
BSDB Spring Meeting: Molecules to Morphogenesis
The British Society for Developmental Biology (BSDB) Spring Meeting Molecules to Morphogenesis was held from 23–26 March 2026 at the University of Warwick (UK). This meeting brought together a vibrant community of researchers to discuss how molecular mechanisms are integrated across scales to drive morphogenesis, spanning diverse model systems and approaches. This preList contains preprints by presenters from the talk and poster sessions at the meeting. Please do get in touch at preLights@biologists.com if you notice any relevant preprints that we may have missed.
| List by | Ingrid Tsang |
October in preprints – Cell biology edition
Different preLighters, with expertise across cell biology, have worked together to create this preprint reading list for researchers with an interest in cell biology. This month, most picks fall under (1) Cell organelles and organisation, followed by (2) Mechanosignaling and mechanotransduction, (3) Cell cycle and division and (4) Cell migration
| List by | Matthew Davies et al. |
September in preprints – Cell biology edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading list. This month, categories include: (1) Cell organelles and organisation, (2) Cell signalling and mechanosensing, (3) Cell metabolism, (4) Cell cycle and division, (5) Cell migration
| List by | Sristilekha Nath et al. |
July in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: (1) Cell Signalling and Mechanosensing (2) Cell Cycle and Division (3) Cell Migration and Cytoskeleton (4) Cancer Biology (5) Cell Organelles and Organisation
| List by | Girish Kale et al. |
June in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: (1) Cell organelles and organisation (2) Cell signaling and mechanosensation (3) Genetics/gene expression (4) Biochemistry (5) Cytoskeleton
| List by | Barbora Knotkova et al. |
May in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) Biochemistry/metabolism 2) Cancer cell Biology 3) Cell adhesion, migration and cytoskeleton 4) Cell organelles and organisation 5) Cell signalling and 6) Genetics
| List by | Barbora Knotkova et al. |
Keystone Symposium – Metabolic and Nutritional Control of Development and Cell Fate
This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.
| List by | Virginia Savy, Martin Estermann |
April in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics
| List by | Vibha SINGH et al. |
March in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) cancer biology 2) cell migration 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) genetics and genomics 6) other
| List by | Girish Kale et al. |
Biologists @ 100 conference preList
This preList aims to capture all preprints being discussed at the Biologists @100 conference in Liverpool, UK, either as part of the poster sessions or the (flash/short/full-length) talks.
| List by | Reinier Prosee, Jonathan Townson |
February in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry and cell metabolism 2) cell organelles and organisation 3) cell signalling, migration and mechanosensing
| List by | Barbora Knotkova et al. |
BSCB-Biochemical Society 2024 Cell Migration meeting
This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.
| List by | Reinier Prosee |
CSHL 87th Symposium: Stem Cells
Preprints mentioned by speakers at the #CSHLsymp23
| List by | Alex Eve |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
| List by | Helen Zenner |
CellBio 2022 – An ASCB/EMBO Meeting
This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.
| List by | Nadja Hümpfer et al. |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
| List by | Osvaldo Contreras |
Single Cell Biology 2020
A list of preprints mentioned at the Wellcome Genome Campus Single Cell Biology 2020 meeting.
| List by | Alex Eve |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
| List by | Madhuja Samaddar et al. |
Lung Disease and Regeneration
This preprint list compiles highlights from the field of lung biology.
| List by | Rob Hynds |
Anticancer agents: Discovery and clinical use
Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.
| List by | Zhang-He Goh |
Biophysical Society Annual Meeting 2019
Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA
| List by | Joseph Jose Thottacherry |
Also in the immunology category:
BSDB Spring Meeting: Molecules to Morphogenesis
The British Society for Developmental Biology (BSDB) Spring Meeting Molecules to Morphogenesis was held from 23–26 March 2026 at the University of Warwick (UK). This meeting brought together a vibrant community of researchers to discuss how molecular mechanisms are integrated across scales to drive morphogenesis, spanning diverse model systems and approaches. This preList contains preprints by presenters from the talk and poster sessions at the meeting. Please do get in touch at preLights@biologists.com if you notice any relevant preprints that we may have missed.
| List by | Ingrid Tsang |
SciELO preprints – From 2025 onwards
SciELO has become a cornerstone of open, multilingual scholarly communication across Latin America. Its preprint server, SciELO preprints, is expanding the global reach of preprinted research from the region (for more information, see our interview with Carolina Tanigushi). This preList brings together biological, English language SciELO preprints to help readers discover emerging work from the Global South. By highlighting these preprints in one place, we aim to support visibility, encourage early feedback, and showcase the vibrant research communities contributing to SciELO’s open science ecosystem.
| List by | Carolina Tanigushi |
Community-driven preList – Immunology
In this community-driven preList, a group of preLighters, with expertise in different areas of immunology have worked together to create this preprint reading list.
| List by | Felipe Del Valle Batalla et al. |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
| List by | Helen Zenner |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
| List by | Osvaldo Contreras |
Single Cell Biology 2020
A list of preprints mentioned at the Wellcome Genome Campus Single Cell Biology 2020 meeting.
| List by | Alex Eve |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Zebrafish immunology
A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.
| List by | Shikha Nayar |
Also in the neuroscience category:
preLighters’ choice – Handpicked DevBio preprints
preLighters with expertise across developmental and stem cell biology have nominated a few developmental biology (and related) preprints they’re excited about and explain in a few paragraph why. Concise preprint highlights, prepared by the preLighter community – a quick way to spot upcoming trends, new methods and fresh ideas.
| List by | Theodora Stougiannou et al. |
BSDB Spring Meeting: Molecules to Morphogenesis
The British Society for Developmental Biology (BSDB) Spring Meeting Molecules to Morphogenesis was held from 23–26 March 2026 at the University of Warwick (UK). This meeting brought together a vibrant community of researchers to discuss how molecular mechanisms are integrated across scales to drive morphogenesis, spanning diverse model systems and approaches. This preList contains preprints by presenters from the talk and poster sessions at the meeting. Please do get in touch at preLights@biologists.com if you notice any relevant preprints that we may have missed.
| List by | Ingrid Tsang |
Keystone Symposium on Stem Cell Models in Embryology 2026
The Keystone Symposium on Stem Cell Models in Embryology, 2026, was organised by Jun Wu (UT Southwestern), Jianping Fu (University of Michigan) and Miki Ebisuya (TU Dresden) and held at Asilomar Conference Grounds in California (US). The meeting discussed recent advances made in establishing stem-cell-based embryo models, what fundamental insights into developmental processes have been gleaned from them, as well as how they are beginning to be applied more widely. This prelist contains preprints by presenters at the talk and poster sessions at the conference, which our Reviews Editor in attendance spotted. Please do reach out to preLights@biologists.com if you notice any that we’ve missed.
| List by | Ingrid Tsang |
November in preprints – DevBio & Stem cell biology
preLighters with expertise across developmental and stem cell biology have nominated a few developmental and stem cell biology (and related) preprints posted in November they’re excited about and explain in a single paragraph why. Concise preprint highlights, prepared by the preLighter community – a quick way to spot upcoming trends, new methods and fresh ideas.
| List by | Aline Grata et al. |
October in preprints – DevBio & Stem cell biology
Each month, preLighters with expertise across developmental and stem cell biology nominate a few recent developmental and stem cell biology (and related) preprints they’re excited about and explain in a single paragraph why. Short, snappy picks from working scientists — a quick way to spot fresh ideas, bold methods and papers worth reading in full. These preprints can all be found in the October preprint list published on the Node.
| List by | Deevitha Balasubramanian et al. |
October in preprints – Cell biology edition
Different preLighters, with expertise across cell biology, have worked together to create this preprint reading list for researchers with an interest in cell biology. This month, most picks fall under (1) Cell organelles and organisation, followed by (2) Mechanosignaling and mechanotransduction, (3) Cell cycle and division and (4) Cell migration
| List by | Matthew Davies et al. |
July in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: (1) Cell Signalling and Mechanosensing (2) Cell Cycle and Division (3) Cell Migration and Cytoskeleton (4) Cancer Biology (5) Cell Organelles and Organisation
| List by | Girish Kale et al. |
May in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) Biochemistry/metabolism 2) Cancer cell Biology 3) Cell adhesion, migration and cytoskeleton 4) Cell organelles and organisation 5) Cell signalling and 6) Genetics
| List by | Barbora Knotkova et al. |
April in preprints – the CellBio edition
A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. This month, categories include: 1) biochemistry/metabolism 2) cell cycle and division 3) cell organelles and organisation 4) cell signalling and mechanosensing 5) (epi)genetics
| List by | Vibha SINGH et al. |
Biologists @ 100 conference preList
This preList aims to capture all preprints being discussed at the Biologists @100 conference in Liverpool, UK, either as part of the poster sessions or the (flash/short/full-length) talks.
| List by | Reinier Prosee, Jonathan Townson |
2024 Hypothalamus GRC
This 2024 Hypothalamus GRC (Gordon Research Conference) preList offers an overview of cutting-edge research focused on the hypothalamus, a critical brain region involved in regulating homeostasis, behavior, and neuroendocrine functions. The studies included cover a range of topics, including neural circuits, molecular mechanisms, and the role of the hypothalamus in health and disease. This collection highlights some of the latest advances in understanding hypothalamic function, with potential implications for treating disorders such as obesity, stress, and metabolic diseases.
| List by | Nathalie Krauth |
‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
| List by | Alex Eve, Katherine Brown |
CSHL 87th Symposium: Stem Cells
Preprints mentioned by speakers at the #CSHLsymp23
| List by | Alex Eve |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
| List by | Helen Zenner |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
| List by | Ana Dorrego-Rivas |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
| List by | Madhuja Samaddar et al. |
SDB 78th Annual Meeting 2019
A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.
| List by | Alex Eve |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Young Embryologist Network Conference 2019
Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London
| List by | Alex Eve |
Also in the pathology category:
preLighters’ choice – Handpicked DevBio preprints
preLighters with expertise across developmental and stem cell biology have nominated a few developmental biology (and related) preprints they’re excited about and explain in a few paragraph why. Concise preprint highlights, prepared by the preLighter community – a quick way to spot upcoming trends, new methods and fresh ideas.
| List by | Theodora Stougiannou et al. |
October in preprints – DevBio & Stem cell biology
Each month, preLighters with expertise across developmental and stem cell biology nominate a few recent developmental and stem cell biology (and related) preprints they’re excited about and explain in a single paragraph why. Short, snappy picks from working scientists — a quick way to spot fresh ideas, bold methods and papers worth reading in full. These preprints can all be found in the October preprint list published on the Node.
| List by | Deevitha Balasubramanian et al. |
October in preprints – Cell biology edition
Different preLighters, with expertise across cell biology, have worked together to create this preprint reading list for researchers with an interest in cell biology. This month, most picks fall under (1) Cell organelles and organisation, followed by (2) Mechanosignaling and mechanotransduction, (3) Cell cycle and division and (4) Cell migration
| List by | Matthew Davies et al. |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
| List by | Osvaldo Contreras |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
| List by | Hiral Shah |
COVID-19 / SARS-CoV-2 preprints
List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic
| List by | Dey Lab, Zhang-He Goh |
1
Cellular metabolism
A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.
| List by | Pablo Ranea Robles |