November in preprints – the CellBio edition
This is the first community-driven preList! A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading lists for researchers with an interest in cell biology. Categories include: 1) cancer cell biology 2) cell cycle and division 3) cell migration and cytoskeleton 4) cell organelles and organisation 5) cell signalling and mechanosensing 6) genetics/gene expression
List by Felipe Del Valle Batalla, Matthew Davies, Sristilekha Nath, Barbora Knotkova, Vibha SINGH, Girish KalePreprints:
Cancer cell biology
DNA repair and anti-cancer mechanisms in the long-lived bowhead whale
https://www.biorxiv.org/content/10.1101/2023.05.07.539748v3
Great preprint that addresses why the very large and long-lived bowhead whale is not so prone to cancer, particularly focussing on DNA repair. It’s relevant because the research question makes total sense and is important but is technically very difficult to address. Here, the authors take on that challenge and thoroughly answer it with a battery of experimental techniques across multiple organisms. Excellent work.
Picked by: Matthew Davies
From Firsanov et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer
https://www.biorxiv.org/content/10.1101/2024.11.15.623825v1
This is an interesting study. Usually cancer stem cells enter quiescence to escape targeting by anti-proliferative chemotherapeutic drugs, re-entering the cell cycle once drug treatment has ended. In this preprint, the authors show that induction and persistence of quiescence by disrupting the MRTF-SRF pathway has therapeutic benefits across a range of cancer lines by preventing re-proliferation.
Picked by: Matthew Davies
From Panesso-Gómez et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Cell cycle and division
Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea
https://www.biorxiv.org/content/10.1101/2024.10.19.619234v2
This is a fantastic preprint on the induction of multicellularity in certain Archaea upon compression, cellularising and developing multiple cell types. It demonstrates tissue-like formation from a unicellular organism in real time.
Picked by: Matthew Davies
From Rados et al. (2024). This image is made available under a CC-BY-NC 4.0 International license.
Membrane oscillations driven by Arp2/3 constrict the intercellular bridge during neural stem cell divisions
https://doi.org/10.1101/2024.10.28.620743
This preprint is interesting as it addresses a fundamental question revolving around cytokinesis during cell division by emphasising how cells, which are part of the tissue and are constrained, complete the cell division process. The authors found a unique phenomenon involving dynamic membrane oscillation mediated by Arp2/3 actin networks.
Picked by: Sristilekha Nath
From LaFoya and Prehoda (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Cell migration and cytoskeleton
Leukocytes use endothelial membrane tunnels to extravasate the vasculature
https://www.biorxiv.org/content/10.1101/2024.10.28.620560v1
This study reveals a novel mechanism of leukocyte transendothelial migration (TEM), where endothelial cells form membrane tunnels to facilitate leukocyte passage.
Picked by: Felipe Del Valle Batalla
YAP controls cell migration and invasion through a Rho-GTPase switch
https://www.biorxiv.org/content/10.1101/602052v3
This preprint identifies YAP-TRIO regulatory invasion and migration pathway, which reveal potential strategies to target invasive cancers such as glioblastoma.
Picked by: Vibha Singh
From Shah et al. (2024). This image is made available under a CC-BY 4.0 International license.
Fishnet mesh of centrin-Sfi1 drives ultrafast calcium-activated contraction of the giant cell Spirostomum ambiguum
https://www.biorxiv.org/content/10.1101/2024.11.07.622534v2
Interesting preprint on how a 1 mm-sized unicellular organism contracts to a quarter of its length in about 5 ms and doesn’t use actomyosin contractility to do that.
Picked by: Girish Kale
From Lannan et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Cell organelles and organisation
Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimer’s Disease-linked pathologies in cultured human neurons
https://www.biorxiv.org/content/10.1101/2024.11.04.621986v1
The authors describe a small molecule that selectively regulates lysosome positioning in neurons. This molecule ameliorates neurodegeneration and Alzheimer’s features.
Picked by: Felipe Del Valle Batalla
From Snead et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Alternative Import-Channels And Destinations Of Mitochondrial PINK1 Controlled By Trans-Membrane-Domain Structural Plasticity
https://doi.org/10.1101/2024.11.06.622366
I think that this is a great preprint that provides fantastic mechanistic details of PINK kinase’s import into mitochondria. It solidifies a direct role of PINK within the matrix of healthy mitochondria and opens up interesting new avenues for targeting PINK in Parkinson’s.
Picked by: Barbora Knotkova
From Lorriman et al. (2024). This image is made available under a CC-BY 4.0 International license.
Vimentin molecular linkages with nesprin-3 enhance nuclear deformations by cell geometric constraints
https://www.biorxiv.org/content/10.1101/2024.10.29.621001v1
The study reveals the role of vimentin (an intermediate filament) in mediating nuclear shape deformation, which, in turn, promotes chromatin condensation under conditions of geometric constraint.
Picked by: Sristilekha Nath
Spectrin coordinates cortical actomyosin organization and differentiation essential for a functional epithelial barrier
https://www.biorxiv.org/content/10.1101/2024.10.17.618796v2.full
This study uncovers the role of cell shape in regulating cell differentiation, which is mediated by cortically recruited Spectrin, thereby promoting barrier functions in the epidermis.
Picked by: Sristilekha Nath
From Soffer et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Automated segmentation of soft X-ray tomography: native cellular structure with sub-micron resolution at high throughput for whole-cell quantitative imaging in yeast
https://www.biorxiv.org/content/10.1101/2024.10.31.621371v1
This preprint is interesting because it uses soft X-ray tomography and deep learning tools for exploring whole-cells and imaging of multi-organelle 3D volumes. This can help with analysis of cell and organelle morphology, interactions, and responses to perturbations.
Picked by: Felipe Del Valle Batalla
Adipose-derived Mesenchymal Stem Cells and Retinal Pigment Epithelial Cells Interactions in Stress Environment via Tunneling Nanotubes
https://www.biorxiv.org/content/10.1101/2024.11.24.624852v1
This is a cool preprint describing the transfer of mitochondria from healthy mesenchymal stem cells to stressed retinal pigment epithelial cells through tunelling nanotubes, allowing recovery. It has implications for potential stem cell-based therapies for retinal disease.
Picked by: Matthew Davies
From Gozel et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Compositional Flexibility of the ER-Mitochondria Encounter Structure
https://doi.org/10.1101/2024.11.26.625358
Preprint that identifies the minimal subunits of the ERMES complex required for lipid transfer between the ER and mitochondria in yeast. It solves the mystery of how the expression of artificial tethers can restore lipid transfer in the absence of other ERMES subunits.
Picked by: Barbora Knotkova
From Covill-Cooke et al. (2024). This image is made available under a CC-BY 4.0 International license.
The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity
https://doi.org/10.1101/2024.11.26.625473
In this preprint, the authors reveal how Hippo and Rho family signaling pathways synergistically regulate actin cytoskeleton organization, bridging the previously assumed non-coordination between them.
Picked by: Vibha Singh
From Murray et al. (2024). This image is made available under a CC-BY-NC 4.0 International license.
Cell signalling and mechanosensing
Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration
https://www.biorxiv.org/content/10.1101/2024.11.11.622870v1
This preprint is amazing! Why: the authors show manipulation of vesicles via magnetogenetics.
Picked by: Felipe Del Valle Batalla
From Gemperle et al. (2024). This image is made available under a CC-BY 4.0 International license.
Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool
https://www.biorxiv.org/content/10.1101/2024.11.12.622506v1
This is a nice preprint. It concerns non-cell autonomous regulation of haematopoeitic stem cells with implications for therapeutic targeting of HSC decline with ageing.
Picked by: Matthew Davies
Membrane potential mediates the cellular response to mechanical pressure
https://doi.org/10.1101/2023.11.02.565386
This preprint identifies membrane potential as the missing link between mechanical force and downstream cellular responses.
Picked by: Barbora Knotkova
From Mukherjee et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signaling pathway
https://doi.org/10.1101/2024.11.04.621794
This preprint reports activation of cellular rejuvenation pathways via epigenetic modifications, when aged dermal fibroblasts were subjected to sustained compressive forces.
Picked by: Sristilekha Nath
From Liu et al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s Disease
https://www.biorxiv.org/content/10.1101/2024.11.18.624141v1
This study is important because it identifies cholesterol dysregulation as a key driver of microglial senescence in Alzheimer’s disease, offering potential new therapeutic targets.
Picked by: Felipe Del Valle Batalla
Piezo1 balances membrane tension and cortical contractility to stabilize intercellular junctions and maintain epithelial barrier integrity
https://www.biorxiv.org/content/10.1101/2024.11.20.624378v1
Preprint describing the role of mechanosensitive ion channel Piezo1 in the mechanically tensed epidermis, where it regulates Tight-junctions and epithelial barrier function.
Picked by: Girish Kale
From Javed et al. (2024). This image is made available under a CC-BY-NC 4.0 International license.
Genetics/gene expression
The 3’-untranslated regions of yeast ribosomal protein mRNAs determine paralog incorporation into ribosomes and recruit factors necessary for specialized functions
https://doi.org/10.1101/2024.03.18.585503
The study represents the first comprehensive analysis of the role of ribosome heterogeneity in yeast under different growth conditions.
Picked by: Barbora Knotkova
From Singh al. (2024). This image is made available under a CC-BY-NC-ND 4.0 International license.
Categories: cell biology
Posted on: 3 December 2024
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Register hereAlso in the cell biology category:
BSCB-Biochemical Society 2024 Cell Migration meeting
This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.
List by | Reinier Prosee |
‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
List by | Alex Eve, Katherine Brown |
preLights peer support – preprints of interest
This is a preprint repository to organise the preprints and preLights covered through the 'preLights peer support' initiative.
List by | preLights peer support |
The Society for Developmental Biology 82nd Annual Meeting
This preList is made up of the preprints discussed during the Society for Developmental Biology 82nd Annual Meeting that took place in Chicago in July 2023.
List by | Joyce Yu, Katherine Brown |
CSHL 87th Symposium: Stem Cells
Preprints mentioned by speakers at the #CSHLsymp23
List by | Alex Eve |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
List by | Helen Zenner |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
Alumni picks – preLights 5th Birthday
This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.
List by | Sergio Menchero et al. |
CellBio 2022 – An ASCB/EMBO Meeting
This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.
List by | Nadja Hümpfer et al. |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
List by | Osvaldo Contreras |
EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)
A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.
List by | Alex Eve |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
List by | Ana Dorrego-Rivas |
Planar Cell Polarity – PCP
This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.
List by | Ana Dorrego-Rivas |
BioMalPar XVI: Biology and Pathology of the Malaria Parasite
[under construction] Preprints presented at the (fully virtual) EMBL BioMalPar XVI, 17-18 May 2020 #emblmalaria
List by | Dey Lab, Samantha Seah |
1
Cell Polarity
Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.
List by | Yamini Ravichandran |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
List by | Maiko Kitaoka et al. |
3D Gastruloids
A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells). Updated until July 2021.
List by | Paul Gerald L. Sanchez and Stefano Vianello |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
List by | Hiral Shah |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
List by | Madhuja Samaddar et al. |
EMBL Seeing is Believing – Imaging the Molecular Processes of Life
Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019
List by | Dey Lab |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
List by | Sandra Malmgren Hill |
Lung Disease and Regeneration
This preprint list compiles highlights from the field of lung biology.
List by | Rob Hynds |
Cellular metabolism
A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.
List by | Pablo Ranea Robles |
BSCB/BSDB Annual Meeting 2019
Preprints presented at the BSCB/BSDB Annual Meeting 2019
List by | Dey Lab |
MitoList
This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.
List by | Sandra Franco Iborra |
Biophysical Society Annual Meeting 2019
Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA
List by | Joseph Jose Thottacherry |
ASCB/EMBO Annual Meeting 2018
This list relates to preprints that were discussed at the recent ASCB conference.
List by | Dey Lab, Amanda Haage |
Also in the cell biology category:
Leukocytes use endothelial membrane tunnels to extravasate the vasculature
Felipe Del Valle Batalla
Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder
Harvey Roweth
Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates
Vanessa Ehlers