Molecular evidence of anteroposterior patterning in adult echinoderms
Posted on: 3 May 2023 , updated on: 27 February 2024
Preprint posted on 5 February 2023
Article now published in Nature at http://dx.doi.org/10.1038/s41586-023-06669-2
Spatial transcriptomics sheds light on the echinoderm body plan! The bilaterian antero- lateral axis shifts to medio-lateral in the ectoderm of adult echinoderms.
Selected by Rodrigo Senovilla-GanzoCategories: bioinformatics, cell biology, evolutionary biology, genetics, genomics, neuroscience, zoology
Updated 27 February 2024 with a postLight by Rodrigo Senovilla-Ganzo
The bioRxiv preprint highlighted here has now been peer-reviewed and published in Nature. This release has attracted both the attention of the general public (through several newspapers) as well as the scientific community (mostly through social media). Its reach was specifically increased by the outreach Nature Video produced by Shamini Bundell (https://www.nature.com/articles/d41586-023-03449-w) and the News&Views article written by Thurston Lacalli (https://www.nature.com/articles/d41586-023-03123-1?utm_medium=Social&utm_source=Twitter#Echobox=1698922903-2).
Comparing the preprint with the published paper reveals that no major modifications have been made in the figures and the overall manuscript. There is, however, a deeper discussion about the origin of the newly identified “ambulacral-anterior” patterning in the peer-reviewed paper. This discussion is focused on the origin of this new patterning mechanism as a recent co-option or ancestral modified form of antero-posterior patterning, highlighting the importance of homalozoan and helicoplacoid echinoderms to unravel this origin.
This group of echinoderms is thought to represent a transitional form between bilateral and pentaradial symmetry. Thus, “re-interpreting these fossils in light of new patterning datasets could allow us to discriminate between co-option with loss of the ancestral axial registry or descent with modification” (Formery et al., 2024). The existence of this transcriptomic evidence will enhance the comparative efforts across echinoderms and chordates. Unfortunately, I’m still missing an online resource with more accessible information for non-bioinformaticians in the evolutionary field.
Overall, the peer-reviewed published version of this bioRxiv preprint does provide improved figures and results, but the main improvement is found in the discussion section; specifically, when the evolutionary origins are addressed. Additionally, the disseminative works produced around this paper—including the mentioned outreach video and News&Views article—are of great value when reaching out to both scientific and non-scientific audiences.
- Why I chose this preprint:
There are three main reasons to consider this paper as disruptive in the evolutionary biology field. Firstly, because of its novelty; spatial transcriptomics is a cutting-edge technology, which is finally reaching evolutionary biology to empower its research. Secondly, because this -omics data, at the same time, overthrows current theories about patterning in echinoderms and leaves the door open for a new paradigm in echinoderm body plan evolution. And last, but not least, due to the thought-provoking head-like theory. The segregation of posterior markers to the mesoderm, and anterior markers to the ectoderm is fascinating, although not unique. The separation between both anterior and posterior gene regulatory networks could have opened up doors for body plan evolution.
- Background:
Living beings are extremely diverse, so to understand their evolutionary relationships, evolutionary developmental biologists have classified them by key features such as the order of appearance of mouth-anus (protostome/deuterostome) or the existence of bilateral symmetry (Cavalier-Smith, 2004). Although echinoderms, like sea urchins and starfish, display a non-bilateral pentaradial symmetry, they are included in the Bilateria clade. The reason behind this allocation is hidden in its larval development.
After gastrulation, the feeding larvae display a bilateral symmetry with several paired arms. However, subsequent metamorphosis leads to a reabsorption of anterior structures into a stacked shape with five not-paired rays (McEdward & Janies, 1993). From a developmental point of view, these early processes have been proven to be shared by sister group hemichordates and chordates. The gastrulation and early patterning of echinoderm bilaterian larvae are guided by Wnt, chordin and BMPs signalling – common pathways for all deuterostomes (Hinman & Burke, 2018; Holland & Anderson, 2015). However, after metamorphosis, the bilateral symmetry must be remodelled into radial symmetry, and the role of patterning genes in this process or even in the metamorphosed adult echinoderm remains a mystery (Figure 1a, b).
In order to explore the expression of these patterning genes in the larvae, the adult, and during metamorphosis, it is key to understand the evolution of radial echinoderms from a bilateral ancestor. Over time, several hypotheses have been proposed to explain adult divergence: bifurcation, circularization, duplication, and stacking (Adachi et al., 2018; Byrne et al., 2016; Luttrell et al., 2012; Peterson et al., 2000; Popodi, E., Andrews, M., & Raff, 1994; Rozhnov & Rozhnov, 2014; Smith, 2008). Bifurcation and circularization have been cast aside due to inconsistency with molecular data. However, duplication and stacking are still under consideration. In the duplication hypothesis (Byrne et al., 2016; Popodi, E., Andrews, M., & Raff, 1994), each of the five echinoderm rays is a copy of the ancestral AP axis, with the anterior ray displaying anterior markers and vice-versa for the posterior ray. In the stacking hypothesis (Adachi et al., 2018; Peterson et al., 2000; Smith, 2008), the oral-aboral axis of adult echinoderms is homologous to the bilaterian AP axis. Thus, the oral part would express anterior markers and the aboral posterior markers; or vice-versa. This hypothesis has been supported by Hox gene expression of the posterior mesoderm. However, broad bilaterian comparisons are normally based on ectodermal expression domains, as the authors of this preprint highlight.
Figure 1: Deployment of the antero-posterior patterning system in deuterostomes. a, Expression map of the conserved transcription factors and signalling ligands involved in ectoderm patterning along the AP axis, as observed in the hemichordate S. kowalveskii. b, Previous work in chordates and hemichordates has demonstrated extensive regulatory conservation in ectodermal AP patterning, establishing the ancestral regulatory characteristics of early deuterostomes. How this system is deployed in echinoderms remains unclear. c, Four hypotheses have been proposed for the deployment of the AP patterning system in establishing the echinoderm adult body plan: bifurcation, circularization, duplication and stacking. Extracted from Figure 1 (Formery et al., 2023).
- Key findings:
The co-opted medio-lateral patterning. Antero-posterior patterning genes, which are responsible for regionalisation across deuterostomes, are expressed in an unexpected manner in echinoderm ectoderm. The markers defining anterior in deuterostomes are expressed in the midline of each array, while those marking posterior are expressed in the most lateral regions. The characterisation of evolutionary co-opted medio-lateral patterning is the major advancement described in this preprint (Figure 2).
Figure 2: Ambulacral-anterior model of echinoderm body plan evolution. a, Expression map of the conserved transcription factors and signalling ligands involved in ambulacral ectoderm patterning in P. miniata and organized from the midline of the ambulacrum (left) towards the interambulacrum (right). b, Diagram of the ambulacral-anterior model in a generalized asteroid with a cross-section through one of the arms. Only genes expressed in the ectoderm are shown. Extracted from Figure 4 (Formery et al., 2023).
Overthrown of current theories. These medial-lateral expression patterns do not match any of the mechanistical hypotheses out there (Formery et al., 2023). Thus, this finding overthrows all current theories about how echinoderm pentaradial symmetry evolved and leaves the door open for speculation.
Lack of trunk genetic markers on echinoderm ectoderm. In the echinoderm mesoderm, HOX genes are expressed in a stacked manner: anterior markers (Hox1-3) are expressed closer to the mouth and posterior genes (Hox11/13) closer to the anus. This patterning model favoured the stacked hypothesis, but now it conflicts with ectoderm expression, which displays a latero-medial expression of anterior (“head”) deuterostome markers. Thus, the mesoderm displays a “trunk” stacked patterning and the ectoderm shows a “head” latero-medial patterning.
Figure 3: Antero-posterior organization of anatomical elements at postmetamorphic stages (Mouth-anus distributed). Hox gene assignments in square brackets represent complementary data from other taxa. Vertical purple arrows represent the somatocoelar hox vectors. Other anatomical elements are indicated in the left scheme. Adapted from David & Mooi, 2014.
The authors of this preprint don’t dwell on this controversy, but they do highlight the concept of “head-like” animals. For Formery and co-authors, this “head-like” [sic] model is a sign of uncoupling between posterior and anterior programs, which seems common in other Echinodermata and Hemichordata (Lacalli, 2014). The decoupling between both tissues, quite unusual for chordates, could have allowed more evolutionary flexibility and could have driven its body plan evolution.
Transcriptomic tool. This article provides an extense transcriptomic resource for the community to consult markers and discuss about a new theory about echinoderm body plan evolution. A valuable contribution to open access science.
- Future directions and questions for the authors (Answers below, at Author’s response)
What new theory is shaped by this data? Could you propose a new paradigm explaining pentaradial symmetry? Can the stacking theory still be plausible for mesoderm, but a new theory might be needed for ectoderm?
What are the patterning differences between larvae and adults? Is echinoderm adult patterning an exacerbation of the differences between echinoderm larvae and hemichordate?
Some of these antero-posterior genes (such as hedgehog, nkx2.1) are dorso-ventral in vertebrates. Did you already observe a different patterning in these vertebrate dorso-ventral genes? Is there a dorso-ventral patterning in echinoderms?
- Bibliography.
Adachi, S., Niimi, I., Sakai, Y., Sato, F., Minokawa, T., Urata, M., Sehara-Fujisawa, A., Kobayashi, I., & Yamaguchi, M. (2018). Anteroposterior molecular registries in ectoderm of the echinus rudiment. Developmental Dynamics : An Official Publication of the American Association of Anatomists, 247(12), 1297–1307. https://doi.org/10.1002/DVDY.24686
Byrne, M., Martinez, P., & Morris, V. (2016). Evolution of a pentameral body plan was not linked to translocation of anterior Hox genes: the echinoderm HOX cluster revisited. Evolution & Development, 18(2), 137–143. https://doi.org/10.1111/EDE.12172
Cavalier-Smith, T. (2004). Only six kingdoms of life. Proceedings of the Royal Society B: Biological Sciences, 271(1545), 1251. https://doi.org/10.1098/RSPB.2004.2705
David, B., & Mooi, R. (2014). How Hox genes can shed light on the place of echinoderms among the deuterostomes. EvoDevo, 5(1), 1–19. https://doi.org/10.1186/2041-9139-5-22/FIGURES/6
Formery, L., Peluso, P., Kohnle, I., Malnick, J., Pitel, M., Uhlinger, K. R., Rokhsar, D. S., Rank, D. R., & Lowe, C. J. (2023). Molecular evidence of anteroposterior patterning in adult echinoderms. BioRxiv, 2023.02.05.527185. https://doi.org/10.1101/2023.02.05.527185
Hinman, V. F., & Burke, R. D. (2018). Embryonic neurogenesis in echinoderms. Wiley Interdisciplinary Reviews: Developmental Biology, 7(4), e316. https://doi.org/10.1002/WDEV.316
Holland, L. Z., & Anderson, P. A. V. (2015). Evolution of basal deuterostome nervous systems. Journal of Experimental Biology, 218(4), 637–645. https://doi.org/10.1242/JEB.109108
Lacalli, T. (2014). Echinoderm conundrums: Hox genes, heterochrony, and an excess of mouths. EvoDevo, 5(1), 1–4. https://doi.org/10.1186/2041-9139-5-46/FIGURES/1
Luttrell, S., Konikoff, C., Byrne, A., Bengtsson, B., & Swalla, B. J. (2012). Ptychoderid Hemichordate Neurulation without a Notochord. Integrative and Comparative Biology, 52(6), 829–834. https://doi.org/10.1093/ICB/ICS117
McEdward, L. R., & Janies, D. A. (1993). Life Cycle Evolution in Asteroids: What is a Larva? Https://Doi.Org/10.2307/1542444, 184(3), 255–268. https://doi.org/10.2307/1542444
Peterson, K. J., Arenas-Mena, C., & Davidson, E. H. (2000). The A/P axis in echinoderm ontogeny and evolution: evidence from fossils and molecules. Evolution & Development, 2(2), 93–101. https://doi.org/10.1046/J.1525-142X.2000.00042.X
Popodi, E., Andrews, M., & Raff, R. A. (1994). Evolution of body plans: using homeobox genes to examine the development of the radial CNS of echinoderms. Developmental Biology, 163, 540.
Rozhnov, S. V., & Rozhnov, S. V. (2014). Symmetry of echinoderms: From initial bilaterally-asymmetric metamerism to pentaradiality. Natural Science, 6(4), 171–183. https://doi.org/10.4236/NS.2014.64021
Smith, A. B. (2008). Deuterostomes in a twist: the origins of a radical new body plan. Evolution & Development, 10(4), 493–503. https://doi.org/10.1111/J.1525-142X.2008.00260.X
doi: https://doi.org/10.1242/prelights.34443
Read preprintSign up to customise the site to your preferences and to receive alerts
Register hereAlso in the bioinformatics category:
Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods
Benjamin Dominik Maier
Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted
Marina Schernthanner
Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Rodrigo Senovilla-Ganzo
Also in the cell biology category:
Motor Clustering Enhances Kinesin-driven Vesicle Transport
Sharvari Pitke
Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis
Ankita Walvekar
Green synthesized silver nanoparticles from Moringa: Potential for preventative treatment of SARS-CoV-2 contaminated water
Safieh Shah, Benjamin Dominik Maier
Also in the evolutionary biology category:
Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Rodrigo Senovilla-Ganzo
Modular control of time and space during vertebrate axis segmentation
AND
Natural genetic variation quantitatively regulates heart rate and dimension
Girish Kale, Jennifer Ann Black
Fetal brain response to maternal inflammation requires microglia
Manuel Lessi
Also in the genetics category:
Intracellular diffusion in the cytoplasm increases with cell size in fission yeast
Leeba Ann Chacko, Sameer Thukral
HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos
Anchel De Jaime Soguero
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA
Leeba Ann Chacko
Also in the genomics category:
A fine kinetic balance of interactions directs transcription factor hubs to genes
Deevitha Balasubramanian
Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Rodrigo Senovilla-Ganzo
Modular control of time and space during vertebrate axis segmentation
AND
Natural genetic variation quantitatively regulates heart rate and dimension
Girish Kale, Jennifer Ann Black
Also in the neuroscience category:
Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal activation
Nicole Bertola
A depth map of visual space in the primary visual cortex
Wing Gee Shum, Phoebe Reynolds
Neural Basis of Number Sense in Larval Zebrafish
Muhammed Sinan Malik
Also in the zoology category:
Blue appendages and temperature acclimation increase survival during acute heat stress in the upside-down jellyfish, Cassiopea xamachana
Maitri Manjunath
How the liver contributes to stomach warming in the endothermic white shark Carcharodon carcharias
Sarah Young-Veenstra
Unlocking the secrets of kangaroo locomotor energetics: Postural adaptations underpin increased tendon stress in hopping kangaroos
EMB EMB_Liv et al.
preListsbioinformatics category:
in the‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
List by | Alex Eve, Katherine Brown |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
Alumni picks – preLights 5th Birthday
This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.
List by | Sergio Menchero et al. |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
List by | Osvaldo Contreras |
Single Cell Biology 2020
A list of preprints mentioned at the Wellcome Genome Campus Single Cell Biology 2020 meeting.
List by | Alex Eve |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
List by | Zhang-He Goh |
Also in the cell biology category:
BSCB-Biochemical Society 2024 Cell Migration meeting
This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.
List by | Reinier Prosee |
‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
List by | Alex Eve, Katherine Brown |
preLights peer support – preprints of interest
This is a preprint repository to organise the preprints and preLights covered through the 'preLights peer support' initiative.
List by | preLights peer support |
The Society for Developmental Biology 82nd Annual Meeting
This preList is made up of the preprints discussed during the Society for Developmental Biology 82nd Annual Meeting that took place in Chicago in July 2023.
List by | Joyce Yu, Katherine Brown |
CSHL 87th Symposium: Stem Cells
Preprints mentioned by speakers at the #CSHLsymp23
List by | Alex Eve |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
List by | Helen Zenner |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
Alumni picks – preLights 5th Birthday
This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.
List by | Sergio Menchero et al. |
CellBio 2022 – An ASCB/EMBO Meeting
This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.
List by | Nadja Hümpfer et al. |
Fibroblasts
The advances in fibroblast biology preList explores the recent discoveries and preprints of the fibroblast world. Get ready to immerse yourself with this list created for fibroblasts aficionados and lovers, and beyond. Here, my goal is to include preprints of fibroblast biology, heterogeneity, fate, extracellular matrix, behavior, topography, single-cell atlases, spatial transcriptomics, and their matrix!
List by | Osvaldo Contreras |
EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)
A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.
List by | Alex Eve |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
List by | Ana Dorrego-Rivas |
Planar Cell Polarity – PCP
This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.
List by | Ana Dorrego-Rivas |
BioMalPar XVI: Biology and Pathology of the Malaria Parasite
[under construction] Preprints presented at the (fully virtual) EMBL BioMalPar XVI, 17-18 May 2020 #emblmalaria
List by | Dey Lab, Samantha Seah |
1
Cell Polarity
Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.
List by | Yamini Ravichandran |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
List by | Maiko Kitaoka et al. |
3D Gastruloids
A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells). Updated until July 2021.
List by | Paul Gerald L. Sanchez and Stefano Vianello |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
List by | Hiral Shah |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
List by | Madhuja Samaddar et al. |
EMBL Seeing is Believing – Imaging the Molecular Processes of Life
Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019
List by | Dey Lab |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
List by | Sandra Malmgren Hill |
Lung Disease and Regeneration
This preprint list compiles highlights from the field of lung biology.
List by | Rob Hynds |
Cellular metabolism
A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.
List by | Pablo Ranea Robles |
BSCB/BSDB Annual Meeting 2019
Preprints presented at the BSCB/BSDB Annual Meeting 2019
List by | Dey Lab |
MitoList
This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.
List by | Sandra Franco Iborra |
Biophysical Society Annual Meeting 2019
Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA
List by | Joseph Jose Thottacherry |
ASCB/EMBO Annual Meeting 2018
This list relates to preprints that were discussed at the recent ASCB conference.
List by | Dey Lab, Amanda Haage |
Also in the evolutionary biology category:
‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
List by | Alex Eve, Katherine Brown |
preLights peer support – preprints of interest
This is a preprint repository to organise the preprints and preLights covered through the 'preLights peer support' initiative.
List by | preLights peer support |
EMBO | EMBL Symposium: The organism and its environment
This preList contains preprints discussed during the 'EMBO | EMBL Symposium: The organism and its environment', organised at EMBL Heidelberg, Germany (May 2023).
List by | Girish Kale |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)
A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.
List by | Alex Eve |
Planar Cell Polarity – PCP
This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.
List by | Ana Dorrego-Rivas |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
List by | Maiko Kitaoka et al. |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
List by | Hiral Shah |
COVID-19 / SARS-CoV-2 preprints
List of important preprints dealing with the ongoing coronavirus outbreak. See http://covidpreprints.com for additional resources and timeline, and https://connect.biorxiv.org/relate/content/181 for full list of bioRxiv and medRxiv preprints on this topic
List by | Dey Lab, Zhang-He Goh |
1
SDB 78th Annual Meeting 2019
A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.
List by | Alex Eve |
Pattern formation during development
The aim of this preList is to integrate results about the mechanisms that govern patterning during development, from genes implicated in the processes to theoritical models of pattern formation in nature.
List by | Alexa Sadier |
Also in the genetics category:
BSDB/GenSoc Spring Meeting 2024
A list of preprints highlighted at the British Society for Developmental Biology and Genetics Society joint Spring meeting 2024 at Warwick, UK.
List by | Joyce Yu, Katherine Brown |
BSCB-Biochemical Society 2024 Cell Migration meeting
This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.
List by | Reinier Prosee |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
Alumni picks – preLights 5th Birthday
This preList contains preprints that were picked and highlighted by preLights Alumni - an initiative that was set up to mark preLights 5th birthday. More entries will follow throughout February and March 2023.
List by | Sergio Menchero et al. |
Semmelweis Symposium 2022: 40th anniversary of international medical education at Semmelweis University
This preList contains preprints discussed during the 'Semmelweis Symposium 2022' (7-9 November), organised around the 40th anniversary of international medical education at Semmelweis University covering a wide range of topics.
List by | Nándor Lipták |
20th “Genetics Workshops in Hungary”, Szeged (25th, September)
In this annual conference, Hungarian geneticists, biochemists and biotechnologists presented their works. Link: http://group.szbk.u-szeged.hu/minikonf/archive/prg2021.pdf
List by | Nándor Lipták |
2nd Conference of the Visegrád Group Society for Developmental Biology
Preprints from the 2nd Conference of the Visegrád Group Society for Developmental Biology (2-5 September, 2021, Szeged, Hungary)
List by | Nándor Lipták |
EMBL Conference: From functional genomics to systems biology
Preprints presented at the virtual EMBL conference "from functional genomics and systems biology", 16-19 November 2020
List by | Jesus Victorino |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
List by | Maiko Kitaoka et al. |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
List by | Hiral Shah |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
List by | Sandra Malmgren Hill |
Zebrafish immunology
A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.
List by | Shikha Nayar |
Also in the genomics category:
BSCB-Biochemical Society 2024 Cell Migration meeting
This preList features preprints that were discussed and presented during the BSCB-Biochemical Society 2024 Cell Migration meeting in Birmingham, UK in April 2024. Kindly put together by Sara Morais da Silva, Reviews Editor at Journal of Cell Science.
List by | Reinier Prosee |
9th International Symposium on the Biology of Vertebrate Sex Determination
This preList contains preprints discussed during the 9th International Symposium on the Biology of Vertebrate Sex Determination. This conference was held in Kona, Hawaii from April 17th to 21st 2023.
List by | Martin Estermann |
Semmelweis Symposium 2022: 40th anniversary of international medical education at Semmelweis University
This preList contains preprints discussed during the 'Semmelweis Symposium 2022' (7-9 November), organised around the 40th anniversary of international medical education at Semmelweis University covering a wide range of topics.
List by | Nándor Lipták |
20th “Genetics Workshops in Hungary”, Szeged (25th, September)
In this annual conference, Hungarian geneticists, biochemists and biotechnologists presented their works. Link: http://group.szbk.u-szeged.hu/minikonf/archive/prg2021.pdf
List by | Nándor Lipták |
EMBL Conference: From functional genomics to systems biology
Preprints presented at the virtual EMBL conference "from functional genomics and systems biology", 16-19 November 2020
List by | Jesus Victorino |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
List by | Maiko Kitaoka et al. |
Also in the neuroscience category:
2024 Hypothalamus GRC
This 2024 Hypothalamus GRC (Gordon Research Conference) preList offers an overview of cutting-edge research focused on the hypothalamus, a critical brain region involved in regulating homeostasis, behavior, and neuroendocrine functions. The studies included cover a range of topics, including neural circuits, molecular mechanisms, and the role of the hypothalamus in health and disease. This collection highlights some of the latest advances in understanding hypothalamic function, with potential implications for treating disorders such as obesity, stress, and metabolic diseases.
List by | Nathalie Krauth |
‘In preprints’ from Development 2022-2023
A list of the preprints featured in Development's 'In preprints' articles between 2022-2023
List by | Alex Eve, Katherine Brown |
CSHL 87th Symposium: Stem Cells
Preprints mentioned by speakers at the #CSHLsymp23
List by | Alex Eve |
Journal of Cell Science meeting ‘Imaging Cell Dynamics’
This preList highlights the preprints discussed at the JCS meeting 'Imaging Cell Dynamics'. The meeting was held from 14 - 17 May 2023 in Lisbon, Portugal and was organised by Erika Holzbaur, Jennifer Lippincott-Schwartz, Rob Parton and Michael Way.
List by | Helen Zenner |
FENS 2020
A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020
List by | Ana Dorrego-Rivas |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
List by | Madhuja Samaddar et al. |
SDB 78th Annual Meeting 2019
A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.
List by | Alex Eve |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
List by | Sandra Malmgren Hill |
Young Embryologist Network Conference 2019
Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London
List by | Alex Eve |